Performance prediction of industrial centrifuges using scale-down models

Boychyn M; Yim SSS; Bulmer M; More J; Bracewell DG; Hoare M

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Performance prediction of industrial centrifuges using scale-down models

机译：使用比例缩小模型预测工业离心机的性能

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Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge (TM)) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.

机译：计算流体动力学被用来模拟在多室碗式离心机进料区中发现的高流动力，并在小型高速旋转盘装置中再现这些力。将设备与按比例缩小的离心机连接在一起，可以很好地估计各种连续流离心机（圆盘堆，多室碗，CARR Powerfuge（TM））对剪切敏感的蛋白质沉淀物的性能。至关重要的是，与中试离心机相比，超小型离心分离工艺被证明是生产多室碗形碗性能更准确的预测指标。

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来源
《Bioprocess and Biosystems Engineering》 |2004年第6期|p. 385-391|共7页
作者
Boychyn M; Yim SSS; Bulmer M; More J; Bracewell DG; Hoare M;
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作者单位

Univ Coll London, London WC1E 7JE, England;

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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词
centrifugation; scale-down; shear; clarification; STACK CENTRIFUGE; FLOW INTENSITY; RECOVERY;

机译：离心;按比例缩小;剪切;澄清;叠层离心;流动强度;回收率;

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Performance prediction of industrial centrifuges using scale-down models

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