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首页> 外文期刊>Bioprocess and Biosystems Engineering >Process modeling of the lipase-catalyzed dynamic kinetic resolution of (R, S)-suprofen 2,2,2-trifluoroethyl thioester in a hollow-fiber membrane
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Process modeling of the lipase-catalyzed dynamic kinetic resolution of (R, S)-suprofen 2,2,2-trifluoroethyl thioester in a hollow-fiber membrane

机译：中空纤维膜中脂肪酶催化（R，S）-suprofen 2,2,2-三氟乙基硫代酯动态动力学拆分的过程模型

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摘要

A Candida rugosa lipase immobilized on polypropylene powder was employed as the biocatalyst for the enantioselective hydrolysis of (R, S)-suprofen 2,2,2-trifluorothioester in cyclohexane, in which trioctylamine was added as the catalyst to perform in situ racemization of the remaining (R)-thioester. A hollow-fiber membrane was also integrated with the dynamic kinetic resolution process in order to continuously extract the desired (S)-suprofen into an aqueous solution containing NaOH. A kinetic model for the whole process (operating in batch and feed-batch modes) was developed, in which enzymatic hydrolysis and deactivation, lipase activation, racemization and non-enantioselective hydrolysis of the substrate by trioctylamine, and reactive extraction of (R)- and (S)-suprofen into the aqueous phase in the membrane were considered. Theoretical predictions from the model for the time-course variations of substrate and product concentrations in each phase were compared with experimental data.
机译：固定在聚丙烯粉末上的皱纹念珠菌脂肪酶用作在环己烷中对映体选择性水解（R，S）-suprofen 2,2,2-trifluorothioester的生物催化剂，其中加入三辛胺作为催化剂进行原位消旋。剩余的（R）-硫酯。中空纤维膜还与动态动力学拆分过程集成在一起，以便将所需的（S）-suprofen连续萃取到含有NaOH的水溶液中。建立了整个过程的动力学模型（分批和进料分批运行），其中酶促水解和失活，脂肪酶活化，外消旋和三辛胺对底物的非对映选择性水解，以及反应性萃取（R）-考虑到膜中水相中的（S）-suprofen。该模型对每个相中底物和产物浓度随时间变化的理论预测与实验数据进行了比较。

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