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Effect of fluid dispersion on cybernetic control of microbial growth on substitutable substrates

机译:流体分散对可替代基质上微生物生长的控制论的影响

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摘要

Many fermentation media contain two or more substrates, which a microorganism utilizes for similar purposes. Depending on the conditions prior to and during a fermentation, the substrates may be utilized in succession or simultaneously. Since it is difficult to portray this behavior through mechanistic models, a cybernetic method was proposed earlier. Here the microorganism chooses the mode of substrate utilization that maximizes its own survival, usually expressed by the growth rate. In a fully dispersed bioreactor, simultaneous utilization generates higher growth rates but leads to low biomass concentrations since this utilization pattern is preferred at low concentrations of the substrates. In this study it has been shown that by allowing less than complete dispersion in the broth it is possible to shift from sequential to simultaneous utilization at high concentrations, thereby enabling both high growth rates and large biomass concentrations. This strategy thus allows the natural incomplete dispersion in large bioreactors to be gainfully exploited.
机译:许多发酵培养基包含两种或多种底物,微生物可将其用于相似目的。根据发酵之前和发酵过程中的条件,可以连续或同时利用底物。由于很难通过机械模型描述这种行为,因此较早提出了控制论方法。在这里,微生物选择底物利用的模式,该模式可以最大化自身的生存能力,通常以增长率表示。在完全分散的生物反应器中,同时利用会产生较高的生长速率,但会导致生物质浓度较低,因为这种利用方式在底物浓度低时是优选的。在这项研究中,已经表明,通过允许在肉汤中分散不完全,可以在高浓度下从连续利用转变为同时利用,从而可以实现高生长速率和高生物量浓度。因此,该策略允许有效利用大型生物反应器中的自然不完全分散。

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