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首页> 外文期刊>Bioprocess and Biosystems Engineering >Computer-aided design of microfluidic resistive network using circuit partition and CFD-based optimization and application in microalgae assessment for marine ecological toxicity
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Computer-aided design of microfluidic resistive network using circuit partition and CFD-based optimization and application in microalgae assessment for marine ecological toxicity

机译：基于电路分割和基于CFD的优化的微流体电阻网络计算机辅助设计及其在海洋生态毒性微藻评估中的应用

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摘要

We present an automatic design process for microfluidic dilution network towards marine ecological toxicity assessment on microalgae. Based on the hydraulic-electric circuit analogy, we defined an abstract specification using computer-aided designing system. Several approaches, especially circuit partition, were applied to minimize design effort. Computational fluid dynamics (CFD) simulation was exploited to convert the electrics specification to fabrication model. We automatically designed the combinational-mixing-serial dilution microfluidics to generate parallel stepwise gradients for mixing chemicals (binary/ternary/quaternary mixture) using the present algorithm. We critically discussed design rules and evaluated the microfluidic performance by colorimetric analysis. To examine whether these microfluidic chips can be used for toxicity test on microalgae, single and joint toxic effects of heavy metals (copper, mercury, zinc, and cadmium) were examined on line. In all cases, dose-related toxic responses were successfully detected. These results provided a solution for designing resistive network using circuit partition and CFD-based optimization and a route to develop a promising user-friendly alternative for microalgae bioassays as well as cell-based screening experiments in risk assessment.
机译：我们提出了一种针对微藻海洋生态毒性评估的微流控稀释网络的自动设计过程。基于液压电路的类比，我们使用计算机辅助设计系统定义了一个抽象规范。应用了几种方法，尤其是电路分区，以最大程度地减少设计工作。利用计算流体动力学（CFD）仿真将电气规范转换为制造模型。我们使用本算法自动设计了混合混合系列稀释微流体，以生成用于混合化学物质（二元/三元/四元混合物）的平行逐步梯度。我们严格讨论了设计规则，并通过比色分析评估了微流控性能。为了检查这些微流控芯片是否可以用于微藻的毒性测试，在线检测了重金属（铜，汞，锌和镉）的单一和联合毒性作用。在所有情况下，均成功检测到剂量相关的毒性反应。这些结果为使用电路分区和基于CFD的优化设计电阻网络提供了解决方案，并为开发微藻生物测定以及风险评估中基于细胞的筛选实验开发有希望的用户友好替代方法提供了途径。

著录项

  • 来源
    《Bioprocess and Biosystems Engineering》 |2019年第5期|785-797|共13页
  • 作者

    Han Bingxu; Zheng Guoxia; Wei Junfeng; Yang Yusuo; Lu Ling; Zhang Qian; Wang Yunhua;

  • 作者单位

    Dalian Univ, Chem & Environm Engn Inst, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Chem & Environm Engn Inst, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Chem & Environm Engn Inst, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Chem & Environm Engn Inst, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Sch Med, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Chem & Environm Engn Inst, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

    Dalian Univ, Sch Med, Dalian 116622, Peoples R China|Dalian Univ, Environm Micro Total Anal Lab, Dalian 116622, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microfluidic network; Computer-aided designing; Circuit partition; Microalgae bioassay;

    机译：微流控网络;计算机辅助设计;电路分区;微藻生物测定;

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