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首页> 外文期刊>Bioprocess and Biosystems Engineering >The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process
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The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process

机译：用inonotus baumii具有综合发酵分离过程的Phelliglidin La的高效生产

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摘要

The phelligridin LA was one of the valuable metabolites synthesized by the medicinal fungus Sanghuang in liquid fermentation. In the improvement of PLA productivity by fermentation, we investigated the optimal conditions for the efficient separation of PLA from the fermentation broth with a chromatographic column packed with the macroporous resin ADS-17. Based on the findings, we further developed an integrated bioreactor system that coupled the fermentation and separation of PLA. Fermentation experiments with the bioreactor system testified the performance of our design in fortification of the PLA production: an improvement of PLA production by 2.14 folds was successfully achieved due to the prompt removal of the PLA, while the formation of hyphae biomass was not affected. Also, the integrated system could afford a simultaneous purification of PLA to a purity of 92.95% with a recovery of 84.3%, which was comparable to that of the PLA purified with an additional process (97.53%), at a reasonable recovery. This study provided a feasible approach for the improved production of PLA by fermentation. Besides, the design of the integrated bioreactor system offered a useful reference for the fermentation process development of fungi for the production of diverse valuable metabolites.
机译：PhElligrivin La是由液体发酵中的药用真菌合成的有价值代谢物之一。在通过发酵改善PLA生产率的过程中，我们研究了利用填充有大孔树脂ADS-17的色谱柱从发酵液中有效分离PLA的最佳条件。基于调查结果，我们进一步开发了一种综合生物反应器系统，耦合发酵和分离PLA。生物反应器系统的发酵实验证明了我们在解放军生产的强化方面的设计表现：由于迅速除去PLA，成功地实现了PLA生产的提高，而菌丝生物质的形成不受影响，成功地实现了2.14折。此外，综合系统可以同时纯化PLA，纯度为92.95％，回收率为84.3％，其与纯化的PLA与另外的方法（97.53％）的合理回收率相当。本研究提供了通过发酵改善PLA的可行方法。此外，集成生物反应器系统的设计为真菌的发酵过程开发提供了有用的作用，用于生产各种有价值的代谢物。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2020年第7期|1141-1151|共11页
  • 作者

    Wang Tianwen; Li Hui; Liang Chen; Sun Shiwei; Liu Ao; Zhu Hu;

  • 作者单位

    Xinyang Normal Univ Coll Life Sci Xinyang 464000 Peoples R China|Xinyang Normal Univ Inst Conservat & Utilizat Agrobioresources Dabie Xinyang 464000 Peoples R China;

    China Univ Petr East China Ctr Bioengn & Biotechnol 66 Changjiang West Rd Qingdao 266580 Peoples R China;

    Xinyang Normal Univ Coll Life Sci Xinyang 464000 Peoples R China|Xinyang Normal Univ Inst Conservat & Utilizat Agrobioresources Dabie Xinyang 464000 Peoples R China;

    China Univ Petr East China Ctr Bioengn & Biotechnol 66 Changjiang West Rd Qingdao 266580 Peoples R China;

    China Univ Petr East China Ctr Bioengn & Biotechnol 66 Changjiang West Rd Qingdao 266580 Peoples R China;

    Fujian Normal Univ Fujian Prov Univ Engn Res Ctr Ind Biocatalysis Coll Chem & Mat Sci 32 Shangsan Rd Fuzhou 350007 Peoples R China;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Phelligridin LA; Inonotus baumii; Macroporous resin; Fermentation and separation integration; Adsorption and desorption; Chromatography;

    机译：phelliglidin la;Inonotus baumii;大孔树脂;发酵和分离整合;吸附和解吸;色谱法;

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