Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila

Manivannan Subramanian; Siddharth Jayakumar; Shlesha Richhariya; Gaiti Hasan

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Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila

机译：分泌神经肽的神经元中IP3受体功能的丧失导致成人果蝇肥胖

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Background Intracellular calcium signaling regulates a variety of cellular and physiological processes. The inositol 1,4,5 trisphosphate receptor (IP3R) is a ligand gated calcium channel present on the membranes of endoplasmic reticular stores. In previous work we have shown that Drosophila mutants for the IP3R (itpr ku ) become unnaturally obese as adults with excessive storage of lipids on a normal diet. While the phenotype manifests in cells of the fat body, genetic studies suggest dysregulation of a neurohormonal axis.

机译：背景技术细胞内钙信号传导调节多种细胞和生理过程。肌醇1,4,5三磷酸受体（IP3R）是存在于内质网状存储膜上的配体门控钙通道。在以前的工作中，我们显示了IP3R的果蝇突变体（itpr ku），由于成年人在正常饮食中过多储存脂质而变得不自然肥胖。尽管表型表现在脂肪细胞中，但遗传研究表明神经激素轴失调。

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《BMC Neuroscience》 |2013年第1期|1-8|共8页
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Manivannan Subramanian; Siddharth Jayakumar; Shlesha Richhariya; Gaiti Hasan;
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Calcium Lipid homeostasis Hyperphagia; Magro;

机译：钙脂稳态食欲亢进;玛格罗;

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1. Loss of IP 3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila [J] . Manivannan Subramanian, Siddharth Jayakumar, Shlesha Richhariya, BMC Neuroscience . 2013,第1期

机译：神经肽的IP 3受体功能的丧失分泌神经元在成人果蝇中导致肥胖症
2. The Inositol 1,4,5-Triphosphate Receptor Expression in Drosophila Suggests a Role for IP3 Signalling in Muscle Development and Adult Chemosensory Functions [J] . Padinjat Raghu, Gaiti Hasan Developmental biology . 1995,第2期

机译：果蝇中的肌醇1,4,5-三磷酸受体表达表明IP3信号在肌肉发育和成人化学感觉功能中的作用
3. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. [J] . Ishii M, Fei H, Friedman JM Proceedings of the National Academy of Sciences of the United States of America . 2003,第18期

机译：GPR7（神经肽B和W的内源性受体）的靶向破坏会导致代谢缺陷和成年肥胖。
4. Functional Characterization of Kisspeptin Receptor Ligands: Activation of Neuropeptide FF Receptors [C] . Ryosuke Misu, Shinya Oish, Kenji Tomita Japanese peptide symposium . 2011

机译：基肽受体配体的功能表征：神经肽FF受体的激活
5. Starved State Dependent Modulation of Olfactory Receptor Neuron Function in Drosophila melanogaster Larvae [D] . Kollala, Sai Sundeep. 2017

机译：果蝇果蝇嗅觉神经元功能的饥饿状态依赖调节。
6. Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila [O] . Manivannan Subramanian, Siddharth Jayakumar, Shlesha Richhariya, 2013

机译：分泌神经肽的神经元中IP3受体功能的丧失导致成人果蝇肥胖
7. Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila [O] . Manivannan Subramanian, Siddharth Jayakumar, Shlesha Richhariya, 2013

机译：分泌神经肽的神经元中IP3受体功能的丧失导致成人果蝇肥胖

Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila

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