...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain and cognition >Different types of working memory binding in epilepsy patients with unilateral anterior temporal lobectomy
【24h】

Different types of working memory binding in epilepsy patients with unilateral anterior temporal lobectomy

机译：癫痫患者单侧颞叶切除术中不同类型的工作记忆结合

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The medial temporal lobe is an important structure for long-term memory formation, but its role in working memory is less clear. Recent studies have shown hippocampal involvement during working memory tasks requiring binding of information. It is yet unclear whether this is limited to tasks containing spatial features. The present study contrasted three binding conditions and one single-item condition in patients with unilateral anterior temporal lobectomy. A group of 43 patients with temporal lobectomy (23 left; 20 right) and 20 matched controls were examined with a working memory task assessing spatial relational binding (object-location), non-spatial relational binding (object-object), conjunctive binding (object-colour) and working memory for single items. We varied the delay period (3 or 6 s), as there is evidence showing that delay length may modulate working memory performance. The results indicate that performance was worse for patients than for controls in both relational binding conditions, whereas patients were unimpaired in conjunctive binding. Single-item memory was found to be marginally impaired, due to a deficit on long-delay trials only. In conclusion, working memory binding deficits are found in patients with unilateral anterior temporal lobectomy. The role of the medial temporal lobe in working memory is not limited to tasks containing spatial features. Rather, it seems to be involved in relational binding, but not in conjunctive binding. The medial temporal lobe gets involved when working memory capacity does not suffice, for example when relations have to be maintained or when the delay period is long.
机译：颞叶内侧是长期记忆形成的重要结构，但其在工作记忆中的作用尚不清楚。最近的研究表明，在需要记忆力的工作记忆任务中海马受累。尚不清楚这是否仅限于包含空间特征的任务。本研究对比了单侧颞叶前叶切除术患者的三种结合条件和一种单项条件。一组43例颞叶切除术患者（左23例；右20例）和20例相匹配的对照组接受了一项工作记忆任务，评估了空间关系绑定（对象-位置），非空间关系绑定（对象-对象），结膜结合（对象颜色）和单个项目的工作记忆。我们改变了延迟时间（3或6 s），因为有证据表明延迟长度可能会调节工作记忆的性能。结果表明，在两种相关性结合条件下，患者的表现均比对照者差，而患者在结膜结合方面没有受损。仅由于长时延试验的不足，发现单项记忆被轻微削弱。总之，在单侧颞叶前叶切除术患者中发现了工作记忆结合缺陷。内侧颞叶在工作记忆中的作用不仅限于包含空间特征的任务。相反，它似乎与关系绑定有关，但与联合绑定无关。当工作记忆容量不足时（例如必须维持关系或延迟时间较长时），内侧颞叶会受累。

著录项

  • 来源
    《Brain and cognition》 |2014年第3期|231-238|共8页
  • 作者

    Bonnie van Geldorp; Zita Bouman; Marc P.H. Hendriks; Roy P.C. Kessels;

  • 作者单位

    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Montessorilaan 3 Room B.02.08, 6525 HR Nijmegen, The Netherlands;

    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Montessorilaan 3 Room B.02.08, 6525 HR Nijmegen, The Netherlands,Epilepsy Centre Kempenhaeghe, Department of Behavioural Sciences, Postbus 61, 5590 AB Heeze, The Netherlands;

    Radboud University Nijmegen Medical Centre, Department of Medical Psychology, Postbus 9101, 6500 HB Nijmegen, The Netherlands,Epilepsy Centre Kempenhaeghe, Department of Behavioural Sciences, Postbus 61, 5590 AB Heeze, The Netherlands;

    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Montessorilaan 3 Room B.02.08, 6525 HR Nijmegen, The Netherlands,Radboud University Nijmegen Medical Centre, Department of Medical Psychology, Postbus 9101, 6500 HB Nijmegen, The Netherlands;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Working memory; Medial temporal lobe; Epilepsy surgery; Associative memory;

    机译：工作记忆;颞中叶;癫痫手术;联想记忆;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号