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首页> 外文期刊>Brain and cognition >Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging
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Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging

机译：功能磁共振成像在自闭症谱系障碍语义处理过程中的大脑激活

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Language and communication deficits are core features of autism spectrum disorders (ASD), even in high-functioning adults with ASD. This study investigated brain activation patterns using functional magnetic resonance imaging in right-handed adult males with ASD and a control group, matched on age, handedness, and verbal IQ. Semantic processing in the controls produced robust activation in Broca's area (left inferior frontal gyrus) and in superior medial frontal gyrus and right cerebellum. The ASD group had substantially reduced Broca's activation, but increased left temporal (Wernicke's) activation. Furthermore, the ASD group showed diminished activation differences between concrete and abstract words, consistent with behavioral studies. The current study suggests Broca's area is a region of abnormal neurodevelopment in ASD, which may be linked with semantic and related language deficits frequently observed in ASD.
机译：语言和沟通障碍是自闭症谱系障碍（ASD）的核心特征，即使在功能强大的成人ASD中也是如此。这项研究使用功能性磁共振成像技术研究了右手成年男性ASD和对照组的大脑激活模式，这些年龄，年龄，惯用性和言语智商相匹配。控件中的语义处理在Broca区域（左前额下回）以及上额额中回和右小脑中产生了强大的激活作用。 ASD组已大大降低了Broca的激活，但增加了左颞（Wernicke）的激活。此外，与行为研究一致，ASD组显示出具体词和抽象词之间的激活差异减小了。目前的研究表明，布罗卡区是ASD中神经发育异常的区域，这可能与ASD中经常观察到的语义和相关语言缺陷有关。

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