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首页> 外文期刊>Brain and cognition >Interactive influence of sex, stressor timing, and the BclI glucocorticoid receptor polymorphism on stress-induced alterations of long-term memory
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Interactive influence of sex, stressor timing, and the BclI glucocorticoid receptor polymorphism on stress-induced alterations of long-term memory

机译：性别，应激源时机和BclI糖皮质激素受体多态性对应激诱导的长期记忆改变的交互影响

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摘要

Certain susceptibility factors, such as genetic variants or specific physiological responses to stress, can dictate the effects of stress on learning and memory. Here, we examined the influence of the BclI polymorphism of the glucocorticoid receptor gene on the time-dependent effects of pre-learning stress on long-term memory. Healthy individuals were exposed to the socially evaluated cold pressor test or a control condition immediately or 30 min before word list learning. Participants' memory for the words was tested immediately and 24 h after learning, and saliva samples were collected to genotype participants for the BclI polymorphism and to assess cortisol responses to the stressor. Results revealed that stress immediately before learning enhanced memory, while stress 30 min before learning impaired memory; these effects were largely selective to males and non-arousing words. Additionally, stress, independent of when it was administered, enhanced memory in non-carriers of the BclI polymorphism, while impairing memory in carriers; these effects were largely selective to males and participants exhibiting a robust cortisol response to stress. These results provide further evidence for time-dependent effects of stress on long-term memory and suggest that carriers of the BclI polymorphism might be more sensitive to the negative effects of corticosteroids on learning.
机译：某些易感性因素，例如遗传变异或对压力的特定生理反应，可以决定压力对学习和记忆的影响。在这里，我们检查了糖皮质激素受体基因的BclI多态性对学习前应激对长期记忆的时间依赖性影响。健康个体立即或在单词表学习之前30分钟接受社会评估的冷压测试或对照条件。在学习后和学习24小时后立即测试参与者对单词的记忆，并收集唾液样本给基因型参与者以了解其BclI多态性并评估皮质醇对应激源的反应。结果显示，学习之前的压力会增强记忆力，而学习之前的30分钟的压力会损害记忆力。这些效果在很大程度上是针对男性和非骚扰性单词的。另外，与施用时间无关，压力增强了BclI多态性非载体中的记忆，同时损害了载体中的记忆。这些作用在很大程度上对男性具有选择性，并且参与者表现出对压力的强烈皮质醇反应。这些结果为压力对长期记忆的时间依赖性作用提供了进一步的证据，并表明BclI多态性的携带者可能对皮质类固醇对学习的负面影响更为敏感。

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  • 来源
    《Brain and cognition》 |2019年第7期|72-83|共12页
  • 作者

    Zoladz Phillip R.; Duffy Tessa J.; Mosley Brianne E.; Fiely Miranda K.; Nagle Hannah E.; Scharf Amanda R.; Brown Callie M.; Earley McKenna B.; Rorabaugh Boyd R.; Dailey Alison M.;

  • 作者单位

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

    Ohio Northern Univ, Raabe Coll Pharm, Dept Pharmaceut & Biomed Sci, Ada, OH 45810 USA;

    Ohio Northern Univ, Dept Psychol Sociol & Criminal Justice, 525 S Main St Hill 013, Ada, OH 45810 USA;

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  • 正文语种 eng
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  • 关键词

    Stress; Memory; Glucocorticoids; Cortisol; Genetics; Polymorphism;

    机译：压力;记忆;糖皮质激素;皮质醇;遗传学;多态性;

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