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首页> 外文期刊>Brain Structure and Function >Projections from the rat pedunculopontine and laterodorsal tegmental nuclei to the anterior thalamus and ventral tegmental area arise from largely separate populations of neurons
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Projections from the rat pedunculopontine and laterodorsal tegmental nuclei to the anterior thalamus and ventral tegmental area arise from largely separate populations of neurons

机译：从大鼠足小脑桥骨和后背被盖核到前丘脑和腹侧被盖区的投影来自很大程度上独立的神经元群体

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Cholinergic and non-cholinergic neurons in the brainstem pedunculopontine (PPT) and laterodorsal tegmental (LDT) nuclei innervate diverse forebrain structures. The cholinergic neurons within these regions send heavy projections to thalamic nuclei and provide modulatory input as well to midbrain dopamine cells in the ventral tegmental area (VTA). Cholinergic PPT/LDT neurons are known to send collateralized projections to thalamic and non-thalamic targets, and previous studies have shown that many of the afferents to the VTA arise from neurons that also project to midline and intralaminar thalamic nuclei. However, whether cholinergic projections to the VTA and anterior thalamus (AT) are similarly collateralized is unknown. Ultrastructural work from our laboratory has demonstrated that cholinergic axon varicosities in these regions differ both morphologically and with respect to the expression and localization of the high-affinity choline transporter. We therefore hypothesized that the cholinergic innervation to these regions is provided by separate sets of PPT/LDT neurons. Dual retrograde tract-tracing from the AT and VTA indicated that only a small percentage of the total afferent population to either region showed evidence of providing collateralized input to the other target. Cholinergic and non-cholinergic cells displayed a similarly low percentage of collateralization. These results are contrasted to a control case in which retrograde labeling from the midline paratenial thalamic nucleus and the VTA resulted in higher percentages of cholinergic and non-cholinergic dual-tracer labeled cells. Our results indicate that functionally distinct limbic target regions receive primarily segregated signaling from PPT/LDT neurons.
机译：脑干pedunculopontine（PPT）和后来的背盖肌（LDT）核中的胆碱能和非胆碱能神经元支配着各种前脑结构。这些区域内的胆碱能神经元向丘脑核发送大量投射信号，并向腹侧被盖区（VTA）的中脑多巴胺细胞提供调节性输入。已知胆碱能PPT / LDT神经元会将附带的投射物发送到丘脑和非丘脑靶标，并且先前的研究表明，许多VTA传入神经源也投射到中线和椎板内丘脑核。但是，尚不清楚是否对VTA和前丘脑（AT）的胆碱能投射进行了类似的抵押。我们实验室的超微结构研究表明，这些区域的胆碱能轴突静脉曲张在形态学以及高亲和力胆碱转运蛋白的表达和定位方面均存在差异。因此，我们假设对这些区域的胆碱能神经支配由单独的PPT / LDT神经元集提供。来自AT和VTA的双重逆行道追踪表明，只有一个地区的总传入人口的一小部分显示了向另一个目标提供抵押投入的证据。胆碱能和非胆碱能细胞显示相似的低抵押率。这些结果与对照例形成对比，在对照例中，来自中线对角膜下丘脑核和VTA的逆行标记导致胆碱能和非胆碱能双示踪剂标记的细胞百分比更高。我们的结果表明功能不同的边缘目标区域主要接收来自PPT / LDT神经元的分离信号。

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