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首页> 外文期刊>Brain Tumor Pathology >Expression of podoplanin and calretinin in meningioma: an immunohistochemical study
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Expression of podoplanin and calretinin in meningioma: an immunohistochemical study

机译：脑膜瘤中Podoplanin和Calretinin的表达：免疫组织化学研究

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Meningioma is derived from arachnoid cells covering the surface of the brain and spinal cord, and it has characteristics shared by mesothelioma arising from the pleura and peritoneum in that it takes an epithelioid appearance despite its mesenchymal origin. We examined the immunohistochemical expression of podoplanin and calretinin, both of which are well-known markers of mesothelioma, in 24 surgical cases of meningioma of various types. In most cases, a linear immunoreactivity for podoplanin was found along the cell surface of most neoplastic cells. An intracytoplasmic, finely granular, or diffuse immunoreactivity was also noted in some cells. These findings corresponded well to immunoreactivity for epithelial membrane antigen (EMA), but immunoreactivity for podoplanin was more crisp or sharply delineated and clear compared with that for EMA. These findings indicate that podoplanin can be used as an immunohistochemical marker that is equivalent to EMA in the differential diagnosis of meningioma. However, most meningiomas did not contain calretinin-immunoreactive cells, a finding that differs from the diffuse immunoreactivity seen in mesothelioma.
机译：脑膜瘤起源于覆盖脑和脊髓表面的蛛网膜细胞，并且具有由胸膜和腹膜引起的间皮瘤共有的特征，尽管其具有间充质起源，但仍呈上皮样外观。我们在24种不同类型的脑膜瘤手术病例中检查了podoplanin和calretinin的免疫组织化学表达，它们都是间皮瘤的著名标志。在大多数情况下，在大多数肿瘤细胞的细胞表面发现了对podoplanin的线性免疫反应性。在某些细胞中还观察到胞质内，细颗粒或弥漫性免疫反应性。这些发现与上皮膜抗原（EMA）的免疫反应性非常吻合，但与EMA相比，podoplanin的免疫反应性更清晰或更清晰。这些发现表明，在脑膜瘤的鉴别诊断中，podoplanin可用作与EMA等效的免疫组织化学标记物。但是，大多数脑膜瘤不包含钙网蛋白免疫反应性细胞，这一发现与间皮瘤中弥漫性免疫反应性不同。

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