...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Breast Cancer Research and Treatment >Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China
【24h】

Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China

机译：北方地区携带TGFB1 rs1982073 C等位基因和FGFR2 rs1219648 G等位基因的汉族女性患乳腺癌的风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The high morbidity and aggressive behavior of breast cancer are associated with genetic variations. Single nucleotide polymorphisms (SNPs) in many genes have been demonstrated as a risk factor for breast cancer. In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China. TaqMan allelic discrimination assay was performed to genotype rs1982073 and rs1219648 in 447 breast cancer cases and 406 age-matched healthy controls. The results imply that genotype frequencies of rs1982073 and rs1219648 were not significantly different between breast cancer patients and healthy controls. However, for TGFB1 SNP rs1982073, the C-carriers (T/C+C/C genotype) were more likely to bear tumors of greater aggressiveness (histological grade III) than T/T-carriers (grade I–II) (OR = 3.45, 95% CI: 1.48–8.00, P = 0.004). For FGFR2 SNP rs1219648, G-carriers (A/G+G/G genotype) were more significantly linked to tumors with lymph node metastasis than those with A/A genotype (lymph node negative) (OR = 1.69, 95% CI: 1.11–2.58, P = 0.016). Therefore, the SNPs of TGFB1 rs1982073 and FGFR2 rs1219648 may contribute to the identification of patients with more aggressive breast cancers among Han women in North China.
机译：乳腺癌的高发病率和侵略性行为与遗传变异有关。已经证明许多基因中的单核苷酸多态性（SNP）是乳腺癌的危险因素。在这项研究中，我们评估了转化生长因子β1（TGFB1）基因中的SNP rs1982073（Leu10Pro）和成纤维细胞生长因子受体2（FGFR2）基因中的SNP rs1219648与女性乳腺癌风险和侵袭性的关联中国北方的汉族。对447例乳腺癌病例和406个与年龄匹配的健康对照者进行了基因型rs1982073和rs1219648的TaqMan等位基因歧视分析。结果表明，在乳腺癌患者和健康对照组之间，rs1982073和rs1219648的基因型频率没有显着差异。但是，对于TGFB1 SNP rs1982073，C携带者（T / C + C / C基因型）比T / T携带者（I–II级）更有可能具有更大的侵袭性（组织学等级III）（OR = 3.45，95％CI：1.48–8.00，P = 0.004）。对于FGFR2 SNP rs1219648，G携带者（A / G + G / G基因型）与具有淋巴结转移的肿瘤比具有A / A基因型（淋巴结阴性）的肿瘤更显着相关（OR = 1.69，95％CI：1.11 –2.58，P = 0.016）。因此，TGFB1 rs1982073和FGFR2 rs1219648的SNPs可能有助于在华北地区的汉族女性中鉴定更具侵略性的乳腺癌患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号