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Immunobiology of Her-2/Neu Transgenic Mice

机译：Her-2 / Neu转基因小鼠的免疫生物学

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Development of the mammary gland is controlled by hormones and many other growth factors. Hyperplasia and neoplasia are thus a likely consequence of alterations in their number and type, or the number and function of their receptors.p185neu, a member of the epidermal growth factor family, is coded by the ErbB-2 oncogene. It is expressed in the normal human breast, but overexpressed and associated with a poor prognosis in 15–30% of breast tumours. Employment of ErbB-2 sequences as vaccinal antigens to induce an immune rejection of such tumours is being investigated in several transgenic animal models. One of the most aggressive models of mammary p185neu-dependent carcinogenesis is that of BALB-neuT mice, which are transgenic for the rat transforming Her-2eu oncogene (a homologue of the human ErbB-2 oncogene). The progression of their early neoplastic lesions can be prevented with both cellular and DNA vaccines coadjuvated by antiangiogenic and immunostimulatory molecules. This suggests that induction of a specific immune reaction against a tumor target antigen may provide a way of preventing the onset of tumours in subjects with a high genetic risk of developing cancer.
机译：乳腺的发育受激素和许多其他生长因子的控制。因此，增生和瘤形成可能是其数量和类型或受体数量和功能改变的结果。表皮生长因子家族成员p185neu由ErbB-2癌基因编码。它在正常人的乳房中表达，但过表达且与15-30％的乳腺肿瘤预后不良有关。在几种转基因动物模型中，正在研究使用ErbB-2序列作为疫苗抗原来诱导此类肿瘤的免疫排斥。哺乳动物p185neu依赖性致癌作用最具侵略性的模型之一是BALB-neuT小鼠模型，可对转化Her-2 / neu癌基因（人ErbB-2癌基因的同系物）的大鼠进行转基因。可以通过抗血管生成和免疫刺激分子共轭的细胞疫苗和DNA疫苗来预防其早期肿瘤性病变的进展。这表明诱导针对肿瘤靶抗原的特异性免疫反应可以提供一种预防具有发生癌症的高遗传风险的受试者中肿瘤发作的方法。

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  • 来源
    《Breast Disease》 |2004年第1期|33-42|共10页
  • 作者

    Tania Pannellini; Guido Forni; Piero Musiani;

  • 作者单位

    Aging Research Center, University G. d'Annunzio Foundation, Chieti, Italy;

    Department of Clinical and Biological Sciences, University of Torino, Italy;

    Aging Research Center, University G. d'Annunzio Foundation, Chieti, Italy;

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