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首页> 外文期刊>Breast Disease >Role of IGF-1R in Mediating Breast Cancer Invasion and Metastasis
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Role of IGF-1R in Mediating Breast Cancer Invasion and Metastasis

机译：IGF-1R在介导乳腺癌侵袭和转移中的作用

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摘要

In this review we bring forward what is currently known about the role of type I insulin-like growth factor receptor (IGF-1R) in mediating breast cancer invasion and metastasis. We begin by addressing how activated IGF-1R could allow pre-cancerous cells to become invasive. To this effect, we discuss clinical reports suggesting that activation of IGF-1R could stimulate ductal carcinoma in situs to become invasive. In the same light, we review basic research from our laboratory showing that IGF-1R differentially regulates the expression of breast cancer progression genes when pre-malignant breast epithelial cells were stimulated with insulin-like growth factor-I (IGF-I) over time. The discussion then turns toward the ability of IGF-1R to stimulate invasion of breast cancer cells that have acquired a malignant phenotype. At this stage of breast cancer, it appears that IGF-I stimulates cells to invade in part by inducing urokinase plasminogen activator. Finally, we consider the potential role of IGF-1R in regulating breast cancer metastases by facilitating angiogenesis and lymphangiogenesis. In support of this idea, there is evidence for IGF-1R in both of these processes through the induction of vascular endothelial growth factors (VEGF_{165} and VEGF_{121}). Thus, IGF-1R affords breast cancer cells many opportunities to become invasive and eventually metastatic. We conclude that disrupting IGF-1R signaling has many important implications in the treatment and management of breast cancer.
机译：在这篇综述中，我们提出了关于I型胰岛素样生长因子受体（IGF-1R）在介导乳腺癌侵袭和转移中的作用的当前已知信息。我们首先讨论激活的IGF-1R如何使癌前细胞具有侵袭性。为了达到这个效果，我们讨论了临床报告，这些报告表明IGF-1R的激活可以刺激部位的导管癌成为浸润性的。同样，我们回顾了实验室的基础研究，结果显示，随着时间的推移，胰岛素样生长因子-I（IGF-I）刺激恶性前乳腺上皮细胞时，IGF-1R差异性调节乳腺癌进展基因的表达。然后，讨论转向IGF-1R刺激已获得恶性表型的乳腺癌细胞侵袭的能力。在乳腺癌的这个阶段，看来IGF-I部分通过诱导尿激酶纤溶酶原激活物来刺激细胞侵袭。最后，我们认为IGF-1R通过促进血管生成和淋巴管生成在调节乳腺癌转移中的潜在作用。支持该观点的证据是，通过诱导血管内皮生长因子（VEGF_ {165}和VEGF_ {121}）在这两个过程中均存在IGF-1R。因此，IGF-1R为乳腺癌细胞提供了许多机会，使其具有浸润性并最终转移。我们得出结论，破坏IGF-1R信号传导在乳腺癌的治疗和管理中具有许多重要意义。

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  • 来源
    《Breast Disease》 |2003年第1期|41-47|共7页
  • 作者

    Jill E. Kucab; Sandra E. Dunn;

  • 作者单位

    Department of Pediatrics, BC Research Institute for Children's and Women's Health, University of British Columbia, Vancouver BC V6R 2T6, Canada;

    Department of Pediatrics, BC Research Institute for Children's and Women's Health, University of British Columbia, Vancouver BC V6R 2T6, Canada;

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