The Insulin-Like Growth Factor (IGF) Family and Breast Cancer

Claire M. Perks; Jeff M.P. Holly

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The Insulin-Like Growth Factor (IGF) Family and Breast Cancer

机译：胰岛素样生长因子（IGF）家庭和乳腺癌

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The IGF family, composed of ligands, receptors, binding proteins and proteases, is critical during development and in the maintenance of normal tissue homeostasis. This review describes the role of the IGF system in the normal breast but focuses on the changes that occur in breast cancer. It discusses the cross-talk which can occur between the IGF family with other signalling pathways, including estrogen, epidermal growth factor (EGF) and integrins. It also describes various cell and animal models which have been developed to elucidate the function and significance of the IGF family in cancer with a view to developing potential therapeutics.

机译：由配体，受体，结合蛋白和蛋白酶组成的IGF家族在发育和维持正常组织动态平衡中至关重要。这篇综述描述了IGF系统在正常乳腺癌中的作用，但着重于乳腺癌中发生的变化。它讨论了在IGF家族与其他信号通路，包括雌激素，表皮生长因子（EGF）和整联蛋白之间可能发生的串扰。它还描述了各种细胞和动物模型，这些模型已经被开发出来以阐明IGF家族在癌症中的功能和意义，以开发潜在的治疗方法。

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《Breast Disease》 |2003年第1期|45-60|共16页
作者
Claire M. Perks; Jeff M.P. Holly;
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Division of Surgery, Department of Hospital Medicine, Level 7, Bristol Royal Infirmary, Bristol, BS2 8HW, UK;

Division of Surgery, Department of Hospital Medicine, Level 7, Bristol Royal Infirmary, Bristol, BS2 8HW, UK;

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1. Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families [J] . H Jernstr?m, T Sandberg, E B?geman, British Journal of Cancer . 2005,第5期

机译：胰岛素样生长因子-1（IGF1）基因型可预测妊娠和激素避孕后的乳房体积，并与循环中的IGF-1水平相关：遗传性乳腺癌家族的年轻女性对早发性乳腺癌风险的影响
2. Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, Pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients. [J] . Helle SI, Anker GB, Tally M, The Journal of Steroid Biochemistry and Molecular Biology . 1996,第3a4期

机译：屈洛昔芬对乳腺癌患者血浆胰岛素样生长因子（IGF）-I，Pro-IGF-IIE，胰岛素样生长因子结合蛋白（IGFBP）-1和IGFBP-3的影响。
3. Clinical significance of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with breast cancer. [J] . Faruk Tas, Senem Karabulut, Elif Bilgin, Tumour biology : . 2014,第9期

机译：乳腺癌患者血清胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的临床意义。
4. Risk Factors of Development of the ROP Including IGF-1 (Insulin-Like Growth Factor 1) Level Changes During First Month of Life [C] . K. Zieba, E. Kasprzak, D. Tomaszkiewicz-Mondry, European Congress of Perinatal Medicine . 2008

机译：在寿命的第一个月内，包括IGF-1（胰岛素样生长因子1）水平变化的ROP危险因素
5. G Protein-coupled Estrogen Receptor 1 (GPER1) and Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) Are Key Components of Tamoxifen Action and the Development of Tamoxifen Resistance in Breast Cancer Cells [D] . Zheng, Yan. 2019

机译：G蛋白偶联雌激素受体1（GPER1）和胰岛素样生长因子结合蛋白1（IGFBP-1）是他莫昔芬作用的关键组分和乳腺癌细胞中他莫昔芬抗性的发育
6. Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families [O] . H Jernström, T Sandberg, E Bågeman, 2005

机译：胰岛素样生长因子-1（IGF1）基因型可预测妊娠和激素避孕后的乳房体积并与循环中的IGF-1水平相关：遗传性乳腺癌家族中年轻女性患早发乳腺癌的风险
7. Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families [O] . Jernström, H, Sandberg, T, Bågeman, E, 2005

机译：胰岛素样生长因子-1（IGF1）基因型可预测妊娠和激素避孕后的乳房体积，并与循环的IGF-1水平相关：遗传性乳腺癌家族的年轻女性对早发性乳腺癌风险的影响

The Insulin-Like Growth Factor (IGF) Family and Breast Cancer

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