Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: a phase 1–2 study

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• 来源
  《British Journal of Haematology》 |2010年第1期|p.58-71|共14页
• 作者

  Bertrand Coiffier; Nedjad Losic; Birgitte Biilmann Rønn; Stéphane Lepretre; Lars Møller Pedersen; Ole Gadeberg; Henrik Frederiksen; Marinus H. J. Van Oers; James Wooldridge; Janusz Kloczko; Jerzy Holowiecki; Andrzej Hellmann; Jan Walewski; Tadeusz Robak; Jørgen Petersen;

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• 作者单位

  Département d’Hématologie, Centre Hospitalier Lyon Sud, Pierre-Benite Cedex, France;

  Biometrics;

  Pharmacometrics Group, Genmab A/S, Copenhagen, Denmark;

  Centre Henri Becquerel, Rouen, France;

  Roskilde Hospital, Roskilde;

  Vejle Hospital, Vejle;

  Odense University Hospital, Odense, Denmark;

  University of Amsterdam, Netherlands;

  The University of Iowa, Iowa City, IA, USA;

  Department of Haematology, Medical University of Bialystok;

  Klinika Hematologii i Transplantacji Szpiku, Katowice;

  Medical University of Gdansk;

  Maria Sklodowska-Curie Memorial Institute and Cancer Centre, Warsaw;

  Medical University of Lodz, Poland;

  Pharmacometrics Group, Genmab A/S, Copenhagen, Denmark;

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• 关键词

  ofatumumab; monoclonal antibody; chronic lymphocytic leukaemia; PK/PD; intravenous infusion;

  机译：奥法单抗;单克隆抗体;慢性淋巴细胞性白血病;PK / PD;静脉输注;