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首页> 外文期刊>British Journal of Pharmacology >Postnatal consequences of prenatal cocaine exposure and myocardial apoptosis: does cocaine in utero imperil the adult heart?
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Postnatal consequences of prenatal cocaine exposure and myocardial apoptosis: does cocaine in utero imperil the adult heart?

机译：产前可卡因暴露和心肌细胞凋亡对产后的影响：宫内可卡因是否会危害成年心脏？

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摘要

Cocaine use is common among pregnant women with a history of substance abuse, and has been shown to cause abnormalities in the heart during fetal and postnatal development. However, mechanisms underlying the detrimental effects of cocaine on the developing heart are not fully understood. In this issue, Bae and Zhang show that prenatal cocaine exposure increases the susceptibility of the postnatal heart to ischemia and reperfusion injury. Their results suggest that myocardial apoptosis induced by cocaine during fetal development may represent one of the mechanisms by which prenatal cocaine exposure exerts its long-term, deleterious consequences on postnatal cardiac function.
机译：可卡因在有吸毒史的孕妇中很常见，并且已显示可卡因在胎儿和产后发育过程中会引起心脏异常。然而，可卡因对发育中心脏的有害作用的潜在机制尚不完全清楚。 Bae和Zhang在本期杂志中表明，产前可卡因暴露会增加产后心脏对局部缺血和再灌注损伤的敏感性。他们的研究结果表明，可卡因在胎儿发育过程中诱导的心肌细胞凋亡可能是产前可卡因暴露对产后心脏功能产生长期有害影响的机制之一。

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