Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexane- carbonyl)-D-phenylalanine (A-4166)

Takao Ikenoue; Megumi Akiyoshi; Shoji Fujitani

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Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexane- carbonyl)-D-phenylalanine (A-4166)

机译：新型口服降糖药（-）-N-（反式-4-异丙基环己烷-羰基）-D-苯丙氨酸（A-4166）的降血糖和促胰岛素作用

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摘要

Although the in vitro insulin-releasing effect of A-4166 was similar to that of sulphonylureas, its hypoglycaemic effect was more rapid and shorter-lasting, associated with rapid absorption and clearance. Thus, A-4166 may be useful in suppressing postprandial hyperglycaemia in patients with non-insulin- dependent diabetes mellitus.

机译：尽管A-4166的体外胰岛素释放作用与磺酰脲类相似，但其降血糖作用更快，持续时间更短，与快速吸收和清除有关。因此，A-4166在抑制非胰岛素依赖型糖尿病患者的餐后高血糖中可能有用。

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来源
《British Journal of Pharmacology》 |1997年第1期|p.137-145|共9页
作者
Takao Ikenoue; Megumi Akiyoshi; Shoji Fujitani;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
A-4166; sulphonylurea; insulin secretion;

机译：A-4166;磺酰脲;胰岛素分泌;

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1. Effect of a New Hypoglycemic Agent, A-4166 [(-)-N-(trans-4-4Isopropyl-cyclohexanecarbonyl)-D-phenylalanine], on Postprandial Blood Glucose Excursion: Comparison with Voglibose and Glibenclamide [J] . Takao Ikenoue, Kyoko Okazaki, Shoji Fujitani, Biological & pharmaceutical bulletin . 1997,第4期

机译：新型降糖药A-4166 [（-）-N-（反式-4-4异丙基-环己烷羰基）-D-苯丙氨酸]对餐后血糖波动的影响：与伏格列波糖和格列本脲比较
2. Comparative Antidiabetic Effects of Leaf and Root Extracts of Tetracarpidium Conophorum and Oral Hypoglycaemic Agents on Alloxan-Induced Diabetic Rats [J] . O.J. Ogbonna, P.M. Udia, L.P. Takem, International Journal of Pure and Applied Sciences and Technology . 2013,第1期

机译：川tra叶和根提取物与口服降糖药对四氧嘧啶致糖尿病大鼠抗糖尿病作用的比较
3. Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC [J] . Yang GL., Liu HY., Li HY., Chromatographia . 2003,第3a4期

机译：RP-HPLC分离新的抗糖尿病药N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸和三种相关化合物
4. In vitro and in vivo removal of oral antidiabetic agents (metformin) using activated carbons [C] . Jo?o Μ.Valente Nabais, C. Galacho, A. Galego, World Conference on Carbon . 2012

机译：使用活性碳体外和体内除去口腔抗糖尿病药剂（二甲双胍）
5. The relationship between the emotional burden of Type 2 Diabetes and glycemic control and differences in emotional burden and glycemic control among individuals treated with oral antidiabetic agents, combination therapy, incretin mimetic, and insulin [D] . Douaihy, Katharine 2008

机译：2型糖尿病患者的情绪负担与血糖控制之间的关系以及口服抗糖尿病药，联合疗法，降钙素模拟物和胰岛素治疗的个体之间情绪负担和血糖控制的差异
6. Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent (−)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166) [O] . Takao Ikenoue, Megumi Akiyoshi, Shoji Fujitani, 1996

机译：新型口服降糖药（-）-N-（反式-4-异丙基环己烷-羰基）-D-苯丙氨酸（A-4166）的降血糖和促胰岛素作用
7. Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (−)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166) [O] . Ikenoue, Takao, Akiyoshi, Megumi, Fujitani, Shoji, 1997

机译：新型口服降糖药（-）-N-（反式-4-异丙基环己烷-羰基）-D-苯丙氨酸（A-4166）的降血糖和促胰岛素作用

Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexane- carbonyl)-D-phenylalanine (A-4166)

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