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首页> 外文期刊>World Journal of Gastroenterology >Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers.
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Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers.

机译：干细胞与癌症：上皮癌中骨髓干细胞的证据。

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摘要

Cancer commonly arises at the sites of chronic inflammation and infection. Although this association has long been recognized, the reason has remained unclear. Within the gastrointestinal tract, there are many examples of inflammatory conditions associated with cancer, and these include reflux disease and Barrettos adenocarcinoma of the esophagus, Helicobacter infection and gastric cancer, inflammatory bowel disease and colorectal cancer and viral hepatitis leading to hepatocellular carcinoma. There are several mechanisms by which chronic inflammation has been postulated to lead to cancer which includes enhanced proliferation in an endless attempt to heal damage, the presence of a persistent inflammatory environment creating a pro-carcinogenic environment and more recently a role for engraftment of circulating marrow-derived stem cells which may contribute to the stromal components of the tumor as well as the tumor mass itself. Here we review the recent advances in our understanding of the contributions of circulating bone marrow-derived stem cells to the formation of tumors in animal models as well as in human beings.
机译：癌症通常发生在慢性炎症和感染部位。尽管早已认识到这种关联，但原因仍不清楚。在胃肠道内，有许多与癌症有关的炎性疾病的例子，包括食道反流疾病和巴雷托斯腺癌，幽门螺杆菌感染和胃癌，炎性肠病和结直肠癌以及导致肝细胞癌的病毒性肝炎。据推测，慢性炎症可通过多种机制导致癌症，其中包括不断增殖以试图治愈损伤，持续存在的炎性环境创造了致癌性环境，以及最近在循环骨髓移植中的作用。来源的干细胞，可能有助于肿瘤的基质成分以及肿瘤块本身。在这里，我们回顾了我们对循环骨髓来源的干细胞对动物模型以及人类肿瘤形成的贡献的理解的最新进展。

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