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首页> 外文期刊>World Journal of Gastroenterology >Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats.
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Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats.

机译：阿司匹林通过激活大鼠A2A腺苷受体减轻胃黏膜炎症。

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AIM: To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines.METHODS: Gastric lesions were produced by oral gavage of aspirin (200 mg/kg) and HCl (0.15 mol/L, 8.0 mL/kg). 4-{3-[6-Amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H- purin-2-yl]-prop-2-ynyl}-cyclohexanecarboxylic acid methyl ester (ATL-146e, 2.5-5 mug/kg, IP) was injected 30 min before the administration of aspirin. Tissue myeloperoxidase (MPO) concentration in gastric mucosa was measured as an index of neutrophil infiltration. Gastric mucosal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were determined by ELISA. Also, we examined the effect of ATL-146e on tissue prostaglandin E2 (PGE2) production and gastric secretion.RESULTS: Intragastric administration of aspirin induced multiple hemorrhagic erosions in rat gastricmucosa. The total length of gastric erosions (ulcer index) in control rats was 29.8+/-7.75 mm and was reduced to 3.8+/-1.42 mm after pretreatment with 5.0 g/kg ATL-146e (P<0.01). The gastric contents of MPO and pro-inflammatory cytokines were all increased after the administration of aspirin and reduced to nearly normal levels by ATL-146e. Gastric mucosal PGE2 concentration was not affected by intraperitoneal injection of ATL-146e.CONCLUSION: The specific adenosine A(2A) receptor agonist, ATL-146e, has potent anti-ulcer effects presumably mediated by its anti-inflammatory properties.
机译：目的：确定特定的腺苷A（2A）受体激动剂（ATL-146e）是否可以改善阿司匹林诱导的大鼠胃粘膜损伤，并减少中性粒细胞的积累和促炎性细胞因子的产生。管的阿斯匹林（200 mg / kg）和HCl（0.15 mol / L，8.0 mL / kg）。 4- {3- [6-氨基-9-（5-乙基氨基甲酰基-3,4-二羟基-四氢呋喃-2-基）-9H-嘌呤-2-基]-丙-2-炔基}-环己烷甲酸在服用阿司匹林前30分钟注射甲基丙烯酸酯（ATL-146e，2.5-5杯/千克，IP）。测量胃粘膜中组织髓过氧化物酶（MPO）浓度作为嗜中性粒细胞浸润的指标。通过ELISA测定胃粘膜浓度的肿瘤坏死因子-α（TNF-α）和白介素-1β（IL-1β）。此外，我们还研究了ATL-146e对组织前列腺素E2（PGE2）产生和胃分泌物的影响。对照大鼠的胃糜烂总长度（溃疡指数）为29.8 +/- 7.75 mm，在用5.0 g / kg ATL-146e预处理后，胃糜烂的总长度减少至3.8 +/- 1.42 mm（P <0.01）。服用阿司匹林后，MPO和促炎细胞因子的胃液含量均增加，而通过ATL-146e降低至接近正常水平。腹膜内注射ATL-146e不会影响胃粘膜PGE2浓度。

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