• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues
【24h】

VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues

机译：肝细胞癌及周围肝硬化肝组织中的VEGF

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HCC) and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay (ELISA) has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues, also correctly pointed out that basic fibroblast growth factor (bFGF) has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.
机译：我们非常感兴趣地阅读了Deli和同事的最新工作。 《世界胃肠病学杂志》上的文章报道了在肝细胞癌（HCC）和肝硬化肝组织中血管内皮生长因子（VEGF）的表达。这项有据可查的工作表明，周围肝硬化肝组织中的VEGF明显高于HCC。作者使用免疫组织化学评估了VEGF的表达。免疫组化染色是评估VEGF阳性染色细胞百分比的有效工具，但不能真正有效地评估其真实VEGF含量。我们和其他人已经报道了通过酶联免疫吸附测定（ELISA）评估VEGF蛋白的有效方法，以评估组织VEGF的表达。因此，我们测试了ELISA方法是否可能是一种有效的工具，以确认数据表明肝硬化周围肝组织中的VEGF含量高于HCC。 Deli和同事还正确地指出，据报道碱性成纤维细胞生长因子（bFGF）可协同作用于VEGF表达。因此，我们还评估了bFGF组织水平，以寻找肝硬化组织中VEGF与bFGF水平之间的假定联系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号