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首页> 外文期刊>World Journal of Gastroenterology >Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma.
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Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma.

机译：在Barrett食管发展为腺癌的过程中，环氧合酶2和上皮生长因子受体上调。

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AIM:To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barretts esophagus (BE).METHODS:COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System.RESULTS:The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression.CONCLUSION:COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis.
机译：目的：探讨Barretts食管（BE）整个过程中环氧合酶-2（COX-2）和上皮生长因子受体（EGFR）的表达。采用免疫组织化学方法检测法：COX-2和EGFR蛋白的表达。确定了详细的细胞形态学变化。结果：计算机成像系统定量检测了COX-2和EGFR的表达。结果：随着BE向食管腺癌（EAC）的发展，COX-2和EGFR的表达均增加。结论：COX-2和EGFR可能在从BE向EAC的逐步发展中协同作用，从而导致癌变。

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