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首页> 外文期刊>World Journal of Gastroenterology >Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma.
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Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma.

机译：食管鳞状细胞癌中人类乳头瘤病毒感染的证据及其流行病学。

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AIM: To look for the evidence of human papilloma virus (HPV) infection in esophageal squamous cell carcinomas (ESCC) and to investigate the potential role and epidemiology of HPV infection in the pathogenesis of esophageal carcinomas in Henan emigrants. METHODS: Papilloma virus(PV) and HPV were determined by Ultrasensive S-P immunohistochemistry (IHC) and in situ hybridization (ISH)in esophageal carcinoma tissues (82 cases) and the normal mucosa (40 cases). RESULTS: IHC revealed that the positive rate of PV was 75.0%, 68.18% and 72.5% respectively while the HPV (16/18-E6) positive rate was 45.0%,36.36%, 37.5%, respectively in esophageal carcinoma tissue specimens from Henan emigrants,the local citizens and patients in Hubei Cancer Hospital.The PV and HPV (16/18-E6) were negative in all normal esophageal mucosa specimens.No correlation was found between HPV in esophageal squamous cell carcinoma tissues and in grade 1-3 esophageal squamous cell carcinoma cells.In situ hybridization showed that the HPV (16/18) DNA positive rate was 30.0%, 31.8%, 25.0%, respectively in the 3 groups of samples.No positive hybridization signal was found in 40 normal esophageal mucosa specimens.The positive rate of HPV (16/18) DNA in the esophageal carcinoma specimens was significantly higher than that in normal mucosa specimens (P<0.05).The positive rate was not different among the 3 groups of esophageal carcinoma tissue specimens (P>0.05). CONCLUSION: HPV infection is high in esophageal carcinoma of Henan emigrants, local residents and patients in Hubei Cancer Hospital.HPV is closely related with esophageal squamous cell carcinoma. HPV infection may play an important role in esophageal squamous cell carcinoma.
机译：目的：寻找人乳头瘤病毒（HPV）感染在食管鳞状细胞癌（ESCC）中的证据，并调查HPV感染在河南移民食管癌发病中的潜在作用和流行病学。方法：采用超敏感S-P免疫组织化学（IHC）和原位杂交（ISH）技术检测食管癌组织（82例）和正常黏膜（40例）中的乳头瘤病毒（PV）和HPV。结果：河南省食管癌组织标本中PV阳性率分别为75.0％，68.18％和72.5％，HPV（16 / 18-E6）阳性率分别为45.0％，36.36％，37.5％。所有正常食管黏膜标本的PV和HPV（16 / 18-E6）均为阴性。在食管鳞状细胞癌组织中和1-3级中，HPV之间没有相关性原位杂交显示3组样品中HPV（16/18）DNA阳性率分别为30.0％，31.8％，25.0％，在40例正常食管粘膜中未发现阳性杂交信号。食管癌标本中HPV（16/18）DNA的阳性率明显高于正常黏膜标本（P <0.05）.3组食管癌组织标本中的阳性率无差异（P > 0.05）。结论：河南移民食管癌，当地居民和湖北省肿瘤医院患者的HPV感染率较高，HPV与食管鳞癌密切相关。 HPV感染可能在食管鳞状细胞癌中起重要作用。

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