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首页> 外文期刊>World Journal of Gastroenterology >Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience.
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Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience.

机译：环氧合酶2在胃肠道癌致癌作用中的作用：个人经历的回顾和报告。

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摘要

Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory drugs (NSAIDs). However,coxibs also have an ability to inhibit tumor development of various kinds the same way that NSAIDs do. Many experimental studies using cell lines and animal models demonstrated an ability to prevent tumor proliferation of COX-2 inhibitors. After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP),which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S. Food and Drug Administration (FDA) immediately approved the clinical use of celecoxib for FAP patients. However, some coxibs were recently reported to increase the risk of serious cardiovascular events including heart attack and stroke. In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum,and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors.
机译：选择性环氧合酶（COX）-2抑制剂（coxibs）被开发为一种消炎药，以避免非甾体类消炎药（NSAIDs）的各种副作用。但是，与NSAID一样，coxib也具有抑制各种肿瘤发生的能力。使用细胞系和动物模型进行的许多实验研究表明，具有预防COX-2抑制剂肿瘤扩散的能力。在对一项患有家族性腺瘤性息肉病（FAP）的患者进行一项针对息肉化学预防研究的随机研究后，该研究表明，用塞来昔布（一种coxib）治疗显着减少了结肠息肉的数量，2000年，美国食品药品监督管理局）立即批准塞来昔布用于FAP患者的临床用途。但是，最近有报道称某些coxib会增加发生严重心血管事件（包括心脏病发作和中风）的风险。在本文中，我们综述了COX-2在食道，胃和结肠直肠等胃肠道癌变过程中的作用，并分析了coxibs预防胃肠道肿瘤的化学前景。

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