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首页> 外文期刊>World Journal of Gastroenterology >Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients.
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Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients.

机译：紫杉醇在晚期胃癌患者恶性腹水中的药代动力学研究。

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摘要

AIM: To examine the paclitaxel concentrations in plasma and ascites after its intravenous administration in patients with ascites due to peritonitis carcinomatosa resulting from advanced gastric cancer. METHODS: Two patients with ascites due to peritonitis carcinomatosa resulting from gastric cancer were included in this study. The paclitaxel concentrations in plasma and ascites were investigated for 72 h in case 1 and 168 h in case 2 after intravenous administration. RESULTS: The paclitaxel concentration in plasma peaked immediately after administration, followed by rapid decrease below the threshold value of 0.1 micromol (85 ng/mL) within 24 h. In contrast,the paclitaxel concentration in ascites increased gradually for 24 h after administration to a level consistent with the level found in plasma. After 24 h the level of paclitaxel in ascites and plasma became similar, with the optimal level being maintained up to 72 h following administration. CONCLUSION: The concentration of paclitaxel in ascites is maintained within the optimal level for the treatment of cancer cells for up to 72 h after intravenous administration. Paclitaxel is a promising drug for the treatment of malignant ascites of gastric cancer.
机译：目的：研究静脉注射紫杉醇对晚期胃癌致腹膜炎致腹水患者腹腔注射后血浆和腹水中紫杉醇的浓度。方法：本研究纳入了两名因胃癌引起的腹膜炎癌致腹水的患者。静脉给药后，病例1和病例2在血浆和腹水中紫杉醇的浓度分别为72 h和168 h。结果：给药后血浆中紫杉醇的浓度立即达到峰值，随后在24小时内迅速降至0.1微摩尔（85 ng / mL）的阈值以下。相反，腹水中紫杉醇的浓度在给药后24小时逐渐增加至与血浆中发现的水平一致的水平。 24小时后，腹水和血浆中紫杉醇的水平变得相似，给药后最佳水平维持至72小时。结论：静脉给药后长达72小时，腹水中紫杉醇的浓度保持在治疗癌细胞的最佳水平内。紫杉醇是用于治疗胃癌恶性腹水的有前途的药物。

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