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首页> 外文期刊>World Journal of Gastroenterology >Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.
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Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.

机译：Ets-1原癌蛋白在胃肠道间质瘤，平滑肌瘤和神经鞘瘤中的表达。

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AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS: Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS: Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4%), six leiomyomas (66.7%), and five schwannomas (83.3%) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P<0.005). However, there was no correlation between Ets-1 expression and clinical risk categories. CONCLUSION: Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.
机译：目的：胃肠道间质瘤（GIST）很少见。 GIST与其他胃肠道间质肿瘤（例如平滑肌瘤和神经鞘瘤）不同。这项研究的目的是调查Ets-1在GIST的生长和分化中的作用。方法：采用免疫组化Ets-1染色法检测了28例GIST，9例平滑肌瘤和6例神经鞘瘤。从长崎大学医院的手术病理档案组织中选择标本。结果：Ets-1蛋白在所有这些肿瘤的细胞质中表达。免疫组织化学染色显示Ets-1阳性的27个GIST（96.4％），六个平滑肌瘤（66.7％）和五个神经鞘瘤（83.3％）为阳性。在GIST和平滑肌瘤之间Ets-1表达有统计学差异（P <0.005）。但是，Ets-1表达与临床风险类别之间没有相关性。结论：Ets-1在GIST，平滑肌瘤和神经鞘瘤的生长和分化中起重要作用。

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