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首页> 外文期刊>World Journal of Gastroenterology >Patient with hepatocellular carcinoma related to prior acute arsenic intoxication and occult HBV: epidemiological, clinical and therapeutic results after 14 years of follow-up.
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Patient with hepatocellular carcinoma related to prior acute arsenic intoxication and occult HBV: epidemiological, clinical and therapeutic results after 14 years of follow-up.

机译:与先前急性砷中毒和隐匿性HBV有关的肝细胞癌患者:随访14年后的流行病学,临床和治疗结果。

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摘要

Little is known about the long-term survivors of acute arsenic intoxication. We present here a clinical case report of a man with chronic hepatitis B virus (HBV) infection who developed hepatocellular carcinoma four years after acute arsenic poisoning. HBsAg was detected in serum in 1990 when he voluntarily donated blood. In 1991, the patient suffered from severe psychological depression that led him to attempt suicide by massive ingestion of an arsenic-containing rodenticide. He survived with polyneuropathy and paralysis of the lower limbs, and has been wheelchair-bound since then. During participation in a follow-up study conducted among HBV carriers, abdominal ultrasound detected a two-centimeter liver mass consistent with hepatocellular carcinoma. The tumor was confirmed by computed tomography (CT) and magnetic resonance image (MRI). Because of his significant comorbidity, the patient received palliative treatment with transarterial lipiodol chemoembolization (TACE) on three occasions (1996, 1997 and 1999). At his most recent visit in May 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound.
机译:对于急性砷中毒的长期幸存者知之甚少。我们在此提供一名慢性乙型肝炎病毒(HBV)感染男子的临床病例报告,该男子在急性砷中毒后四年发展为肝细胞癌。 1990年,当他自愿献血时,在血清中检测到HBsAg。 1991年,该患者患有严重的心理抑郁症,导致他大量摄入含砷的灭鼠药而自杀。他在多发性神经病和下肢瘫痪中幸存下来,此后一直坐轮椅。在参加对HBV携带者进行的随访研究期间,腹部超声检查发现与肝细胞癌一致的两厘米肝肿块。通过计算机断层扫描(CT)和磁共振图像(MRI)确认了肿瘤。由于其严重的合并症,该患者在三种情况下(1996年,1997年和1999年)接受了经动脉血栓碘油化学栓塞(TACE)的姑息治疗。在2005年5月的最近一次访问中,该患者无症状,肝酶正常,超声检查表明肿瘤缓解。

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