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首页> 外文期刊>World Journal of Gastroenterology >Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+ strains: an immunohistochemical study.
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Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+ strains: an immunohistochemical study.

机译：感染cagA +菌株的成年患者的幽门螺杆菌相关慢性胃炎中细胞角蛋白的表达：一项免疫组织化学研究。

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AIM: To investigate the expression of different cytokeratins (CKs) in gastric epithelium of adult patients with chronic gastritis infected with Helicobacter pylori (H pylori) cagA+ strains. METHODS: The expression of CK 7, 8, 18, 19 and 20 was studied immunohistochemically in antral gastric biopsies of 84 patients. All the CKs were immunostained in cagA+H pylori gastritis (57 cases), non-H pylori gastritis (17 cases) and normal gastric mucosa (10 cases). RESULTS: In cagA+ H pylori gastritis, CK8 was expressed comparably to the normal antral mucosa from surface epithelium to deep glands. Distribution of CK18 and CK 19 was unchanged, i.e. transmucosal, but intensity of the expression was different in foveolar region in comparison to normal gastric mucosa. Cytokeratin 18 immunoreactivity was significantly higher in the foveolar epithelium of H pylori-positive gastritis compared to both H pylori-negative gastritis and controls. On the contrary, decrease in CK19 immunoreactivity occurred in foveolar epithelium of H pylori-positive gastritis. In both normal and inflamed antral mucosa without H pylori infection, CK20 was expressed strongly/moderately and homogeneously in surface epithelium and upper foveolar region, but in H pylori -induced gastritis significant decrease of expression in foveolar region was noted. Generally, in both normal antral mucosa and H pylori-negative gastritis, expression of CK7 was not observed, while in about half cagA+ H pylori-infected patients, moderate focal CK7 immunoreactivity of the neck and coiled gland areas was registered, especially in areas with more severe inflammatory infiltrate. CONCLUSION: Alterations in expression of CK 7, 18, 19 and 20 together with normal expression of CK8 occur in antral mucosa of H pylori-associated chronic gastritis in adult patients infected with cagA+ strains. Alterations in different cytokeratins expression might contribute to weakening of epithelial tight junctions observed in H pylori-infected gastric mucosa.
机译：目的：研究感染幽门螺杆菌cagA +的成年慢性胃炎患者胃上皮细胞中不同细胞角蛋白的表达。方法：采用免疫组织化学方法对84例胃窦活检组织中CK 7、8、18、19和20的表达进行了研究。所有CK均在cagA + H幽门胃炎（57例），非H幽门胃炎（17例）和正常胃黏膜（10例）中免疫染色。结果：在cagA +幽门螺杆菌胃炎中，从表面上皮到深腺，CK8的表达与正常胃窦粘膜相当。 CK18和CK19的分布不变，即透粘膜，但与正常胃粘膜相比，在叶小叶区域的表达强度不同。与幽门螺杆菌阴性胃炎和对照组相比，幽门螺杆菌阳性胃炎的小叶上皮细胞角蛋白18的免疫反应性明显更高。相反，幽门螺杆菌阳性胃炎的小叶上皮细胞CK19免疫反应性降低。在没有幽门螺杆菌感染的正常和发炎的胃窦粘膜中，CK20在表面上皮和上叶小叶区域强烈/中度和均一地表达，但是在幽门螺杆菌诱导的胃炎中，在叶小叶区域表达明显降低。通常，在正常的胃窦粘膜和幽门螺杆菌阴性胃炎中均未观察到CK7的表达，而在大约一半的受cagA +幽门螺杆菌感染的患者中，颈部和盘绕腺区域的中度局灶性CK7免疫反应得到了证实，特别是在更严重的炎症浸润。结论：在感染cagA +菌株的成年患者中，幽门螺杆菌相关性慢性胃炎的胃黏膜中CK 7、18、19和20的表达以及CK8的正常表达均发生了改变。在幽门螺杆菌感染的胃粘膜中观察到的不同细胞角蛋白表达的改变可能有助于减弱上皮紧密连接。

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