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首页> 外文期刊>World Journal of Gastroenterology >Efficacy of one-day quadruple therapy for H pylori infection in Chinese patients.
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Efficacy of one-day quadruple therapy for H pylori infection in Chinese patients.

机译：一日四联疗法对中国患者幽门螺杆菌感染的疗效。

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摘要

AIM: To compare the efficacies of one-day quadruple therapy and seven-day triple therapy in Chinese patients. METHODS: Sixty consecutive patients with nonulcer dyspepsia and confirmed H pylori infection were randomized to receive either omeprazole 40 mg, amoxycillin 1 g, and furazolidone 100 mg, all twice a day for 7 d or omeprazole 20 mg (at breakfast and dinner), amoxicillin 1 g, furazolidone 200 mg, and colloidal bismuth subcitrate 220 mg four times for only one day. H pylori status was determined before and at least 5 weeks after therapy by endoscopy with antral and corpus biopsies for rapid urease test and histology. RESULTS: H pylori eradication was successful in 66.67% (20/30) patients in the 7-d group and in 36.67% (11/30) patients in the 1-d group (P = 0.037). Side effects were induced by the treatment in 13.3% (4/30) patients of each group, but these were all self-limiting, short-lasting, and did not require any specific treatment. CONCLUSION: The one-day quadruple therapy is less effective than the one-week regimen in curing H pylori infection in Chinese patients.
机译：目的：比较一天四联疗法和七天三联疗法在中国患者中的疗效。方法：连续60例非溃疡性消化不良并确诊为H幽门螺杆菌感染的患者，随机接受奥美拉唑40 mg，阿莫西林1 g和呋喃唑酮100 mg，每天两次，共7 d，或奥美拉唑20 mg（早餐和晚餐），阿莫西林1克，呋喃唑酮200毫克和次柠檬酸铋胶体220毫克，仅一天四次。幽门螺杆菌的状态是在治疗前和治疗后至少5周通过胃镜和肛门活检进行尿素酶快速检测和组织学检查。结果：在7天组中成功根除幽门螺杆菌的患者为66.67％（20/30），在1天组中成功率为36.67％（11/30）患者（P = 0.037）。每组的13.3％（4/30）患者通过治疗诱发了副作用，但是这些都是自限性的，持续时间短的，不需要任何特殊的治疗。结论：在中国患者中，一日四联疗法在治疗幽门螺杆菌感染方面不如一周方案有效。

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