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首页> 外文期刊>World Journal of Gastroenterology >Contribution of genetics to a new vision in the understanding of inflammatory bowel disease.
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Contribution of genetics to a new vision in the understanding of inflammatory bowel disease.

机译：遗传学对理解炎症性肠病的新视野的贡献。

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摘要

Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory autoimmune conditions of the gastrointestinal tract. Other organs, such as the eyes, skin and articulations, are often affected and IBD may be accompanied by other diseases of autoimmune origin. There is no single etiological factor responsible for the onset of IBD. Recent advances in genetics and in the molecular mechanisms of the proteins coded by these genes have given rise to a new vision in understanding these complex diseases. Activation of specific genes that affect antigen presentation and the handling of cells by innate immunity may lead to autoimmunity with the consequent activation of the major histocompatibility complex (MHC) and multiple cytokines involved in the regulation of acquired immunity. In this review IBD is described as a constellation of diseases that can best be classified as barrier diseases. This vision, developed by Kiel in Germany, includes the idea that changes in our environment due to the westernization of civilization have not been met with adaptation of the innate immune system, and this has given rise to autoimmune diseases. These diseases affect 1-5 of 1000 individuals and represent a major burden on the national health systems of many countries on different continents. On a world scale, a major challenge is to generate interventions to prevent the development of these diseases in Asia, Latin America and Africa.
机译：克罗恩氏病（CD）和溃疡性结肠炎（UC）等炎症性肠病（IBD）是胃肠道的慢性炎症性自身免疫病。其他器官（例如眼睛，皮肤和关节）经常受到感染，IBD可能伴有其他自身免疫性疾病。没有单一的病因可引起IBD的发作。这些基因编码的蛋白质的遗传学和分子机制方面的最新进展为理解这些复杂疾病带来了新的视野。通过先天性免疫影响抗原呈递和细胞处理的特定基因的激活可能导致自身免疫，进而激活主要的组织相容性复合体（MHC）和参与调节获得性免疫的多种细胞因子。在本综述中，IBD被描述为可以最好地归类为障碍性疾病的疾病群。由德国基尔（Kiel）提出的这一构想包括这样的思想，即由于文明的西化而导致的环境变化无法通过先天免疫系统的适应来实现，这引起了自身免疫性疾病。这些疾病影响了1000人中的1-5人，对不同大陆上许多国家的国家卫生系统构成了重大负担。在世界范围内，一项重大挑战是在亚洲，拉丁美洲和非洲采取干预措施来预防这些疾病的发展。

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