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首页> 外文期刊>World Journal of Gastroenterology >Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran.
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Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran.

机译：伊朗慢性乙型肝炎患者白介素-1R受体拮抗剂基因的多态性。

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AIM: To investigate the relationships between polymorphisms of interleukin-1R receptor antagonist genes and susceptibility to chronic hepatitis B in Iran population. METHODS: Genomic DNA was extracted from the peripheral blood of 80 patients with chronic hepatitis B (57 males, 23 females) aged 12-77 years (mean 36.1 +/- 13.8 years) and 147 normal controls (96 males, 51 females) aged 6-75 years (mean 41 +/- 18.7 years) who referred to a liver clinic of Tehran and then subjected to polymerase chain reaction (PCR) amplification. PCR products were resolved on a 3% agarose gel and stained with ethidium bromide. RESULTS: Only three of the five kinds of polymorphism (2/2, 2/4, and 4/4) were found in this study. The frequencies of 2/2, 2/4, and 4/4 were 12.5%, 17.5%, 70% respectively in chronic hepatitis B patients and 6.8%, 24.5%, and 68.7% respectively in controls. IL-1 R allele 2 was detected in 30% of chronic hepatitis B patients and in 31.3% of controls, while IL-1 R allele 4 was detected in 87.5% of chronic hepatitis B patients and in 93.2% of controls. The frequency of IL-1R alleles 2 and 4 was detected in 21.25% and 78.75% of the patients and 19.04% and 80.96% of the controls, respectively. CONCLUSION: Our results suggest that the carriage of IL-1R receptor antagonist alleles 2, 4, 6 may not play any role in the development of HBV infection. Large population-based studies are needed to investigate the role of IL-1 polymorphisms in the pathogenesis of developing chronic hepatitis B.
机译：目的：探讨白细胞介素1R受体拮抗剂基因多态性与伊朗人群对慢性乙型肝炎的易感性之间的关系。方法：从80例12-77岁（平均36.1 +/- 13.8岁）的慢性乙型肝炎患者（平均36.1 +/- 13.8岁）和147例正常对照（96例男性，51例女性）的外周血中提取基因组DNA。 6-75岁（平均41 +/- 18.7岁）转至德黑兰的肝脏诊所，然后进行了聚合酶链反应（PCR）扩增。将PCR产物在3％琼脂糖凝胶上分离，并用溴化乙锭染色。结果：在这项研究中发现了五种多态性中的三种（2 / 2、2 / 4和4/4）。慢性乙型肝炎患者的2 / 2、2 / 4和4/4频率分别为12.5％，17.5％，70％，而对照组分别为6.8％，24.5％和68.7％。在30％的慢性乙型肝炎患者和31.3％的对照中检测到IL-1 R等位基因2，而在87.5％的慢性B型肝炎患者和93.2％的对照中检测到IL-1 R等位基因4。 IL-1R等位基因2和4的频率分别在21.25％和78.75％的患者以及19.04％和80.96％的患者中被检测到。结论：我们的结果表明IL-1R受体拮抗剂等位基因2、4、6的携带可能在乙肝病毒感染的发生中没有任何作用。需要大量基于人群的研究来调查IL-1多态性在慢性乙型肝炎发病机理中的作用。

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