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首页> 外文期刊>World Journal of Gastroenterology >Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment.
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Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment.

机译：治疗结束后6个月，具有持续病毒学应答的慢性丙型肝炎患者的长期结果。

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AIM: To assess the clinical, biochemical, and virological outcome during long-term follow-up of chronic hepatitis C patients with sustained virological response following effective antiviral therapy. METHODS: This study was a retrospective cohort study including 171 sustained responders defined as HCV RNA PCR negative at 6 mo after the end of effective antiviral treatment (SVR-6). Clinical signs and symptoms, biochemical hepatic parameters, ultrasonography and HCV RNA PCR were followed. RESULTS: Mean follow-up period was 35.38 +/- 22.2 mo after the end of treatment. Twenty-seven (15.8%) responders had evidence of cirrhosis before treatment. Forty-eight (28.1%), 107 (62.6%) and 6 (3.5%) patients were genotype 1, 3, and 6 respectively, while 10 patients (5.8%) were unclassified. There were no virological and biochemical relapses during the period of follow-up. None of the patients showed evidence of hepatic decompensation. However, there were 3 patients (1.8%) developing hepatocellular carcinoma at 14, 18, 29 mo after treatment discontinuation, two of whom had evidence of cirrhosis prior to therapy. CONCLUSION: The study shows that during a follow-up interval for about 3 years in 171 chronic hepatitis C patients with sustained viral response after effective antiviral treatment there were no evident signs of either biochemical or clinical relapse of liver disease in all but three patients who developed hepatocellular carcinoma.
机译：目的：评估在长期抗病毒治疗后持续病毒学应答的慢性丙型肝炎患者的长期随访中的临床，生化和病毒学结果。方法：这项研究是一项回顾性队列研究，包括171名持续应答者，定义为有效抗病毒治疗（SVR-6）结束后6个月HCV RNA PCR阴性。跟踪临床体征和症状，肝生化指标，超声检查和HCV RNA PCR。结果：治疗结束后平均随访时间为35.38 +/- 22.2 mo。二十七（15.8％）名应答者在治疗前有肝硬化的证据。基因型1、3和6的患者分别为48（28.1％），107（62.6％）和6（3.5％），而未分类的患者为10​​（5.8％）。在随访期间没有病毒学和生化学复发。没有患者显示出肝功能不全的证据。但是，有3例（1.8％）在停药后14、18、29个月发展为肝细胞癌，其中2例在治疗前有肝硬化的迹象。结论：研究表明，在171例接受有效抗病毒治疗后持续病毒反应的慢性丙型肝炎患者，在大约3年的随访期内，除三名患者外，所有患者均无肝病生化或临床复发的明显迹象发生肝细胞癌。

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