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首页> 外文期刊>World Journal of Gastroenterology >H pylori and host interactions that influence pathogenesis.
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H pylori and host interactions that influence pathogenesis.

机译：幽门螺杆菌和宿主相互作用会影响发病机理。

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摘要

H pylori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduodenal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory response that becomes chronic, along with a detectable adaptive immune response, these responses are ineffective in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they interact with the host epithelium to influence pathogenesis.
机译：幽门螺杆菌可能是全世界最普遍的人类病原体。自1983年Marshall和Warren最初提出它与胃炎和消化性溃疡疾病有关以来，幽门螺杆菌也与胃癌有关，被归为I类致癌物。在过去的二十年中，一个值得注意的研究机构揭示了这种革兰氏阴性细菌激活导致人类十二指肠疾病的多种过程。大多数感染是在生命的早期获得的，并且可能在个体的生命中持续存在。当被感染的人发炎性反应变得慢性，以及可检测到的适应性免疫反应时，这些反应在清除感染方面是无效的。幽门螺杆菌具有独特的功能，可使其在胃环境的苛刻条件下驻留，并逃避宿主的免疫反应。在这篇综述中，我们讨论了这种细菌表达的各种毒力因子，以及它们如何与宿主上皮相互作用以影响发病机理。

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