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首页> 外文期刊>World Journal of Gastroenterology >Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs.
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Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs.

机译：比格犬肝脏治疗性草药配方Chunggan提取物的毒理学研究。

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AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis. RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug. CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.
机译：目的：通过系统急性和亚急性毒理学研究，评估传统上被指定为肝治疗药物的中草药提取物（CGX）的药物安全性。方法：在急性和亚急性毒理学研究中，分别给20只雄性狗和20只雌性狗喂食的剂量分别是临床推荐药物剂量的50倍和4倍。通过使用临床体征，尸检，组织病理学发现，血液学，尿液分析和生化分析比较正常组和给药组之间的差异，检查不良反应。结果：在急性研究中，雄性或雌性狗单次服用CGX 5 g / kg时，体重，腹泻，无磷，死亡率和主要器官组织病理学均未见变化。任何剂量的该药物在组织病理学，血液学，尿液分析和生化分析中均未发现药物引起的异常。结论：CGX被认为在具有广泛治疗指数的临床应用中非常安全。

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