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首页> 外文期刊>World Journal of Gastroenterology >Non-invasive measurement of pan-colonic pressure over a whole digestive cycle: Clinical applications of a capsule-style manometric system.
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Non-invasive measurement of pan-colonic pressure over a whole digestive cycle: Clinical applications of a capsule-style manometric system.

机译：在整个消化周期内无结肠结肠压力的无创测量：胶囊式测压系统的临床应用。

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AIM: To study the prolonged colonic motility under normal conditions with a novel capsule-style micro-system and to assess its clinical significance. METHODS: A single use telemetry capsule (10 mm in diameter, 20 mm in length) embedded with a pressure sensor was ingested by the subjects. The sensor is capable of transmitting colonic pressure wirelessly for more than 130 h. The time of capsule entering the segmental colon was detected by ultrasound. The ultrasonic electrodes were mounted on the surface of the ileocecum and navel and at the junction of the left and rectosigmoid colon of the subjects in sequence, which were identified by abdominal X-rays with radiopaque markers. To verify the accuracy and reliability of ultrasonic detection of telemetry capsules at key points of colon, the segmental colonic transit time was simultaneously recorded by using radiopaque markers. RESULTS: The signal lamp showed that all recorders could receive the radio signal transmitted by the telemetry capsule. The X-rays showed that all telemetry capsules were detected successfully when they were passing through the key points of colon. There was a significant correlation between the transit results obtained by ultrasonic detection or by radiopaque markers. Colorectal recording was obtained from 20 healthy subjects during 613 h (411 h during waking, 202 h during sleep). Compared to waking, the number of pressure contractions and the area under pressure contractions were significantly (P < 0.05) decreased during sleep (21 +/- 5 h(-1) vs 15 +/- 4 h(-1), 463 +/- 54 mmHg multiply s/min vs 342 +/- 45 mmHg multiply s/min). The colonic motility exhibited significant regional variations both in the circadian behavior and in response to waking and meal. CONCLUSION: The capsule-style micro-system is reliable and noninvasive, and may represent a useful tool for the study of physiology and pathology of colonic motor disorders.
机译：目的：利用新型胶囊式微系统研究正常条件下结肠蠕动的延长，并评估其临床意义。方法：受试者摄入了内置有压力传感器的一次性遥测胶囊（直径10毫米，长度20毫米）。该传感器能够无线传输结肠压力超过130小时。通过超声检测胶囊进入节段结肠的时间。超声电极依次安装在回肠盲肠和肚脐的表面以及受试者的左乙状结肠和直肠乙状结肠的交界处，并通过带有不透射线标记的腹部X射线进行识别。为了验证在结肠关键点进行遥测胶囊超声检测的准确性和可靠性，使用不透射线的标记同时记录了节段性结肠通过时间。结果：信号灯显示所有记录仪均可接收遥测舱发送的无线电信号。 X射线显示，所有遥测胶囊通过结肠关键点时均被成功检测到。通过超声检测或不透射线标记物获得的转运结果之间存在显着相关性。从613小时（醒来时411小时，睡眠时202小时）的20位健康受试者获得了结直肠记录。与醒来相比，睡眠期间的压力收缩次数和受压收缩面积显着减少（P <0.05）（21 +/- 5 h（-1）vs 15 +/- 4 h（-1），463 + /-54毫米汞柱乘以s / min与342 +/- 45毫米汞柱乘以s / min）。结肠运动在昼夜节律行为以及对苏醒和进食的反应中均表现出明显的区域变化。结论：胶囊式微系统可靠且无创，可能代表研究结肠运动障碍的生理学和病理学的有用工具。

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