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首页> 外文期刊>World Journal of Gastroenterology >Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis.
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Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis.

机译：小儿非酒精性脂肪性肝炎肝纤维化的非侵入性评估。

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摘要

AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify childrenwith NASH who might have fibrotic deposition in the liver.
机译：目的：确定69例非酒精性脂肪性肝病（NAFLD）引起的非酒精性脂肪性肝炎（NASH）患儿肝纤维化的独立预测因子。方法：所有临床怀疑为NASH的患者均进行了肝活检以作为确证性检查。在基线时检查了以下临床和生化变量，作为组织学纤维化的可能预测指标：年龄，体重指数（BMI），收缩压（SBP），舒张压（DBP），空腹血糖，空腹胰岛素，稳态模型评估用于胰岛素抵抗（HOMA-IR），胆固醇，Tryglicerides，丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），AST / ALT比，γ谷氨酰胺转移酶（GT），血小板计数，凝血酶原时间（PT）。结果：在组织学上，28例（40.6％）无纤维化，41例（59.4％）轻度至桥接纤维化。在多变量分析中，BMI> 26.3是纤维化的唯一独立预测因子（OR = 5.85，95％CI = 1.6-21）。结论：BMI有助于鉴别出可能患有肝纤维化沉积的NASH患儿。

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