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首页> 外文期刊>World Journal of Gastroenterology >Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.
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Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.

机译：氟伐他汀对非甾体类抗炎药诱导的大鼠回肠溃疡形成的抑制作用。

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AIM: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats. METHODS: The effects of three HMG-CoA reductase inhibitors, fluvastatin, pravastatin and atorvastatin on ileal ulcer formation in 5-bromo-2-(4-fluorophenyl)-3-(4- methylsulfonylphenyl) thiophene (BFMeT)-treated rats were examined. Antioxidative activity of the inhibitors was measured by a redox-linked colorimetric method. RESULTS: Fluvastatin, which was reported to have antioxidative activity, repressed the ileal ulcer formation in rats treated with BFMeT an NSAIDs. However, the other HMG-CoA reductase inhibitors (pravastatin and atorvastatin) did not repress the ileal ulcer formation. Among these HMG-CoA reductase inhibitors, fluvastatin showed a significantly stronger reducing power than the others (pravastatin, atorvastatin). CONCLUSION: Fluvastatin having the antioxidaitive activity suppresses ulcer formation in rats induced by NSAIDs.
机译：目的：非甾体类抗炎药（NSAIDs）会引起胃肠道损害，这是它们在人类和实验动物中的副作用之一。脂质过氧化在NSAID诱导的溃疡中起重要作用。这项研究的目的是研究3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂对大鼠小肠溃疡的抑制作用。方法：研究了三种HMG-CoA还原酶抑制剂氟伐他汀，普伐他汀和阿托伐他汀对5-溴-2-（4-氟苯基）-3-（4-甲基磺酰基苯基）噻吩（BFMeT）治疗的大鼠回肠溃疡形成的影响。 。通过氧化还原连接的比色法测量抑制剂的抗氧化活性。结果：据报道具有抗氧化活性的氟伐他汀可抑制经BFMeT和NSAIDs治疗的大鼠回肠溃疡的形成。但是，其他HMG-CoA还原酶抑制剂（普伐他汀和阿托伐他汀）不能抑制回肠溃疡的形成。在这些HMG-CoA还原酶抑制剂中，氟伐他汀显示出比其他抑制剂（普伐他汀，阿托伐他汀）明显更强的还原能力。结论：具有抗氧化活性的氟伐他汀可抑制非甾体抗炎药诱导的大鼠溃疡形成。

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