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首页> 外文期刊>World Journal of Gastroenterology >Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma.
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Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma.

机译：幽门螺杆菌感染和血清胃蛋白酶原I水平低是胃癌的危险因素。

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AIM: To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a case-control study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylori -negative patients. METHODS: H pylori CagA and parietal cell antibodies (PCAs), and serum pepsinogen I (SPGI) levels were compared between patients with gastric cancer and controls who received endoscopic examination due to reasons other than gastrointestinal malignancy. RESULTS: The odds ratio (OR) for gastric cancer was 2.9 (95% CI 1.4-5.8) in H pylori + patients, and 2.4 (95% CI 1.2-4.9) in CagA+ patients. When results of H pylori and CagA antibodies were combined, OR increased to 5.0 (95% CI 2.5-10.0). Furthermore, if cardia cancer patients were excluded, the OR increased to 6.8 (95% CI 3.1-14.8). Among patients with a low SPGI level, the OR was 12.0 (95% CI 4.1-35.3). However, the risk was significant only in the older age group. The number of patients with low SPGI was significantly higher in H pylori -/CagA+ patients as compared to other cancer patients. CONCLUSION: Examination of both H pylori and CagA antibodies increases the OR for gastric cancer in our case-control study. CagA antibodies are important in detecting previous H pylori infection in advanced atrophic gastritis or cancer when spontaneous decline of H pylori antibodies occurs. SPGI may be helpful in screening elderly gastric cancer patients.
机译：目的：在一项病例对照研究中，研究检查CagA抗体是否可以增加胃癌的几率，以及在幽门螺杆菌阴性患者中多久发现一次其他血清胃癌风险标志物。方法：比较胃癌患者和因胃肠道恶性肿瘤以外的原因接受内镜检查的对照组患者的幽门螺杆菌CagA和壁细胞抗体（PCA）以及血清胃蛋白酶原I（SPGI）水平。结果：幽门螺杆菌+患者胃癌的优势比（OR）为2.9（95％CI 1.4-5.8），CagA +患者胃癌的优势比为2.4（95％CI 1.2-4.9）。当将幽门螺杆菌和CagA抗体的结果合并时，OR增加到5.0（95％CI 2.5-10.0）。此外，如果排除card门癌患者，则OR增至6.8（95％CI 3.1-14.8）。在SPGI水平低的患者中，OR为12.0（95％CI 4.1-35.3）。但是，该风险仅在年龄较大的人群中才显着。与其他癌症患者相比，幽门螺杆菌-/ CagA +患者中SPGI低的患者人数明显更高。结论：在我们的病例对照研究中，同时检测幽门螺杆菌和CagA抗体会增加胃癌的OR。当H幽门抗体自发性下降时，CagA抗体对于检测晚期萎缩性胃炎或癌症中先前的H幽门感染至关重要。 SPGI可能有助于筛查老年胃癌患者。

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