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首页> 外文期刊>World Journal of Gastroenterology >Impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy on hepatocellular carcinoma cell killing.
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Impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy on hepatocellular carcinoma cell killing.

机译：延长分数剂量传递时间模拟强度调制放射治疗对肝癌细胞杀伤的影响。

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AIM: To explore the impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy (IMRT) on cell killing of human hepatocellular carcinoma (HCC) HepG2 and Hep3B cell lines. METHODS: The radiobiological characteristics of human HCC HepG2 and Hep3b cell lines were studied with standard clonogenic assays, using standard linear-quadratic model and incomplete repair model to fit the dose-survival curves. The identical methods were also employed to investigate the biological effectiveness of irradiation protocols modeling clinical conventional fractionated external beam radiotherapy (EBRT, fraction delivery time 3 min) and IMRT with different prolonged fraction delivery time (15, 30, and 45 min). The differences of cell surviving fraction irradiated with different fraction delivery time were tested with paired t-test. Factors determining the impact of prolonged fraction delivery time on cell killing were analyzed. RESULTS: The alpha/ beta and repair half-time (T(1/2)) of HepG2 and Hep3b were 3.1 and 7.4 Gy, and 22 and 19 min respectively. The surviving fraction of HepG2 irradiated modeling IMRT with different fraction delivery time was significantly higher than irradiated modeling EBRT and the cell survival increased more pronouncedly with the fraction delivery time prolonged from 15 to 45 min, while no significant differences of cell survival in Hep3b were found between different fraction delivery time protocols. CONCLUSION: The prolonged fraction delivery time modeling IMRT significantly decreased the cell killing in HepG2 but not in Hep3b. The capability of sub-lethal damage repair was the predominant factor determining the cell killing decrease. These effects, if confirmed by clinical studies, should be considered in designing IMRT treatments for HCC.
机译：目的：探讨延长剂量传递时间建模强度调节放射治疗（IMRT）对人肝细胞癌（HCC）HepG2和Hep3B细胞系杀伤的影响。方法：使用标准的线性二次模型和不完全修复模型，以拟合剂量生存曲线，通过标准克隆形成法研究人肝癌HepG2和Hep3b细胞系的放射生物学特性。还使用相同的方法来研究模拟临床常规分次外束放射疗法（EBRT，分次递送时间3分钟）和IMRT的辐照方案的生物学有效性，延长分次递送时间（15、30和45分钟）不同。用配对t检验测试了以不同的分数递送时间照射的细胞存活分数的差异。分析了决定延长分数递送时间对细胞杀伤的影响的因素。结果：HepG2和Hep3b的alpha / beta和修复半衰期（T（1/2））分别为3.1和7.4 Gy，分别为22和19分钟。不同分次递送时间的HepG2辐照模型IMRT的存活分数显着高于辐照模型EBRT，并且随着分次递送时间从15分钟延长到45分钟，细胞存活率显着增加，而在Hep3b中未发现明显的细胞存活率差异在不同的分数传输时间协议之间。结论：IMRT延长级分传递时间可以显着降低HepG2细胞的杀伤力，而不能降低Hep3b细胞的杀伤力。亚致死损伤修复的能力是决定细胞杀伤力下降的主要因素。如果临床研究证实了这些效果，则在设计用于肝癌的IMRT治疗时应考虑这些效果。

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