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首页> 外文期刊>World Journal of Gastroenterology >A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
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A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.

机译：消旋卡多曲和洛哌丁胺用于终止成人急性腹泻的盲目，随机对照。

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AIM: Racecadotril is a specific enkephalinase inhibitor that exhibits intestinal antisecretory activity without affecting intestinal transit. Loperamide is an effective anti-diarrheal agent, but it usually induces constipation. This study is to compare the efficacy, safety, and tolerability of racecadotril versus loperamide in the outpatient treatment of acute diarrhea in adults. METHODS: A two-center, randomized, parallel-group, single-blind study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg thrics daily) and loperamide (2.0 mg 2 twics daily) in 62 adult patients suffering from acute diarrhea. The main efficacy criterion used was the duration of diarrhea after beginning the treatment (in hours). Other signs and symptoms were also evaluated. RESULTS: The clinical success rates for these anti-diarrheal treatments were 95.7% and 92.0% for racecadotril and loperamide respectively. Patients on racecadotril had a median duration of diarrhea of 19.5 h compared with a median of 13 h for patients on loperamide. Rapid improvement in anal burn and nausea was found for each drug. However, more patients on loperamide suffered from reactive constipation (29.0% vs 12.9%). Itching, another adverse event was notably higher in the racecadotril group (28.6% vs 0%). With regard to other adverse events, the two medications showed similar occurrence rates and similar concomitant medication usage rates. CONCLUSION: Racecadotril and loperamide are rapid, equally effective treatments for acute diarrhea in adults, but loperamide treatment is associated with a higher incidence of treatment-related constipation.
机译：目的：卡卡地普是一种特殊的脑啡肽酶抑制剂，在不影响肠道转运的情况下具有肠抗分泌活性。洛哌丁胺是一种有效的止泻药，但通常会引起便秘。这项研究旨在比较消旋卡多曲和洛哌丁胺在成人急性腹泻的门诊治疗中的疗效，安全性和耐受性。方法：进行了一个双中心，随机，平行分组的单盲研究，以比较62例成年患者中消旋卡多曲（每日100 mg thrics）和洛哌丁胺（每日2.0 mg 2 twic）的疗效，耐受性和安全性患有急性腹泻。使用的主要疗效标准是开始治疗后的腹泻持续时间（小时）。还评估了其他体征和症状。结果：消旋卡多曲和洛哌丁胺的抗腹泻治疗的临床成功率分别为95.7％和92.0％。消旋卡多曲的腹泻持续时间中位数为19.5小时，而洛哌丁胺的腹泻持续时间中位数为13小时。发现每种药物的肛门烧伤和恶心都有快速改善。但是，更多接受洛哌丁胺治疗的患者发生了反应性便秘（29.0％比12.9％）。瘙痒，在消旋卡多曲组中另一个不良事件显着更高（28.6％比0％）。关于其他不良事件，两种药物显示相似的发生率和相似的伴随药物使用率。结论：卡西多利和洛哌丁胺是成人急性腹泻的快速，同等有效的治疗方法，但洛哌丁胺治疗与治疗相关性便秘的发生率更高。

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