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首页> 外文期刊>World Journal of Gastroenterology >Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV.
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Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV.

机译：肝癌复发危险因素的临床分析及其与乙肝的关系。

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AIM: To comprehend the risk factors of recurrence of hepatocellular carcinoma (HCC) and its relationship with the infection patterns of hepatitis B virus (HBV). METHODS: All materials of 270 cases of postoperative HCC were statistically analyzed by SPSS software. Recurrence and metastasis were classified into early (<=2 years) and late phase (>2 years). Risk factors for recurrence and metastasis after surgery in each group were analyzed. RESULTS: Out of 270 cases of HCC, 162 cases were followed up in which recurrence and metastasis occurred in 136 cases. There were a lot of risk factors related to recurrence and metastasis of HCC; risk factors contributing to early phase recurrence were serum AFP level, vascular invasion, incisal margin and operative transfusion, gross tumor classification and number of intrahepatic node to late phase recurrence. The HBV infective rate of recurrent HCC was 94.1%, in which HBsAg, HBeAb, HbcAb HBV infection in solitary large hepatocellular carcinoma (SLHCC) evidently decreased compared to nodular hepatocellular carcinoma (NHCC) (P<0.05). CONCLUSION: The early and late recurrence and metastasis after hepatectomy of HCC were associated with different risk factors. The early recurrence may be mediated by vascular invasion and remnant lesion, the late recurrence by tumor's clinical pathology propert, as multicentric carcinogenesis or intrahepatic carcinoma de novo. HBV replication takes a great role in this process. From this study, we found that SLHCC has more satisfactory neoplasm biological behavior than NHCC.
机译：目的：了解肝细胞癌（HCC）复发的危险因素及其与乙型肝炎病毒（HBV）感染方式的关系。方法：采用SPSS软件对270例术后HCC患者的所有资料进行统计分析。复发和转移分为早期（<= 2年）和晚期（> 2年）。分析各组术后复发和转移的危险因素。结果：在270例肝癌中，有162例被随访，其中136例发生了复发和转移。肝癌复发转移的危险因素很多。导致早期复发的危险因素包括血清AFP水平，血管浸润，切缘和手术输血，肿瘤的大体分类和肝内至晚期复发的结节数目。复发性HCC的HBV感染率为94.1％，其中结节性肝细胞癌（NHCC）的HBsAg，HBeAb，HbcAb HBV感染在孤立性大肝癌（SLHCC）中明显降低（P <0.05）。结论：肝癌肝切除术后早期和晚期复发转移与不同的危险因素有关。早期复发可能是由血管浸润和残余病变所介导的，晚期复发是由肿瘤的临床病理特征所介导的，如多中心癌变或新发肝内癌。 HBV复制在此过程中起着重要作用。通过这项研究，我们发现SLHCC比NHCC具有更令人满意的肿瘤生物学行为。

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