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首页> 外文期刊>World Journal of Gastroenterology >Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer.
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Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer.

机译：胰腺癌中p53和mdm2蛋白表达的临床病理意义。

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AIM: To study the clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. METHODS: To investigate the expression of p53 and mdm2 in pancreatic cancer by immunohistochemistry, and the relationships between the p53 and mdm2 protein expression and clinicopathological parameters in pancreatic cancer. RESULTS: The positive expression of p53 protein was found in 40 of 59 patients (67.8%) and that of mdm2 protein in 17 of 59 patients (28.8%). No obvious relationships were found between p53 as well as mdm2 expression and sex, tumor site, TNM staging and histological differentiation. p53 expression was increased in patients younger than 65 years old, while mdm2 had no relationship with age. The survival time of the patients with the positive expression of p53 and mdm2 proteins was obviously shorter than the other groups. CONCLUSION: Both p53 and mdm2 presented relatively high expression in human pancreatic cancer. The overexpression of p53 and mdm2 might reflect the malignant proliferation of pancreatic cancer and their co-expression might be helpful to evaluate the prognosis of the patients with pancreatic cancer.
机译：目的：研究p53和mdm2蛋白在胰腺癌中的临床病理意义。方法：采用免疫组织化学方法研究胰腺癌中p53和mdm2的表达，以及胰腺癌中p53和mdm2蛋白表达与临床病理参数的关系。结果：59例患者中有40例（67.8％）发现p53蛋白阳性表达，59例患者中有17例（28.8％）发现mdm2蛋白阳性表达。在p53以及mdm2表达与性别，肿瘤部位，TNM分期和组织学分化之间未发现明显的关系。 65岁以下的患者中p53表达增加，而mdm2与年龄无关。 p53和mdm2蛋白阳性表达的患者的生存时间明显短于其他各组。结论：p53和mdm2在人胰腺癌中均表达较高。 p53和mdm2的过表达可能反映了胰腺癌的恶性增生，它们的共同表达可能有助于评估胰腺癌患者的预后。

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