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首页> 外文期刊>World Journal of Gastroenterology >Extended radical operation of pancreatic head cancer: Appraisal of its clinical significance
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Extended radical operation of pancreatic head cancer: Appraisal of its clinical significance

机译：胰头癌扩大根治术的临床意义评估

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AIM: To evaluate the significance of extended radical operation and its indications. METHODS: Between January 1995 and December 1998, 56 inpatients with pancreatic head cancer received operation. Among them 35 patients (group 1) experienced the Whipple operation, and 21 patients (group 2) received the extended radical operation. The 1-, 2-, 3-year cumulative survival rates were used to evaluate the efficacy of the two operative procedures. Clinical stage (CS) was assessed retrospectively with the help of CT. The indications for extended radical operation were discussed. RESULTS: There was no difference in hospital mortality and morbidity rates. Whereas the 1-, 2-, 3-year cumulative survival rates were 84.8%, 62.8%, 39.9% in the extended radical operation group, and were 70.8%, 47.6%, 17.2% in the Whipple operation group, there was a significant difference between the two groups (P<0.001, P<0.001, P<0.001, respectively). Most of the deaths within 3 years after operation were due to recurrence in the two groups. However, the 1-, 2-, 3-year cumulative rates of death due to local recurrence were decreased from 37.4% in patients that received the Whipple procedure to 23.8% in those who received by extended radical operation. Patients who survived for more than 3 years were only noted in those with CS1 in the Whipple procedure group and were founded in cases with CS1, CS2 and part of CS3 in the extended radical operation group. CONCLUSION: The extended radical operation appears to benefit patients with pancreatic head carcinoma which was indicated in CS1, CS2 and part of CS3 without severe invasion.
机译：目的：评估扩大根治手术的意义及其适应症。方法：在1995年1月至1998年12月之间，共有56例胰头癌住院患者接受了手术。其中35例（第1组）经历了Whipple手术，而21例（第2组）接受了扩大的根治性手术。 1、2、3年的累积生存率用于评估两种手术方法的疗效。借助CT回顾性评估了临床分期（CS）。讨论了扩大根治性手术的适应症。结果：医院死亡率和发病率没有差异。延长的根治性手术组的1、2、3年累计生存率分别为84.8％，62.8％，39.9％，而Whipple手术组分别为70.8％，47.6％，17.2％，两组之间的差异（分别为P <0.001，P <0.001，P <0.001）。术后3年内的死亡多数是由于两组复发。但是，因局部复发而导致的1年，2年，3年累计死亡率从接受Whipple手术的患者的37.4％降低到接受长期根治性手术的患者的23.8％。存活超过3年的患者仅在Whipple手术组中有CS1的患者中发现，而在扩大的根治性手术组中有CS1，CS2和CS3的部分患者才被发现。结论：扩大的根治性手术似乎有益于胰头癌患者，这在CS1，CS2和部分CS3中没有明显的侵袭。

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