• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Changes of gastrointestinal myoelectric activity and bile acid pool size after cholecystectomy in guinea pigs
【24h】

Changes of gastrointestinal myoelectric activity and bile acid pool size after cholecystectomy in guinea pigs

机译：豚鼠胆囊切除术后胃肠肌电活动和胆汁酸池大小的变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To investigate the bile acid pool size after cholecystectomy whether or not correlated to the gastrointestinal migrating myoelectric complex (MMC) in guinea pigs. METHODS: Gallbladder motilities were assessed before cholecystectomy. Furthermore, we continuously monitored interdigestive gastrointestinal motilities using bipolar electrodes in conscious guinea pigs before and after surgery at 4 wk in standard diet group and high cholesterol diet (cholesterol gallstone) group. Total bile acid pool sizes were measured by isotope dilution method at meantime. RESULTS: After cholecystectomy, there were parallel falls in duration of phase Ⅰ, Ⅱ, Ⅲ and MMC cycle duration but increase in amplitude in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones. However, There were not significantly differences.On the other hand, the bile acid pool was definitely small in the GS guinea pigs compared to normal guinea pigs and became slightly smaller after cholecystectomy. Similarly, bile acid in gallbladder bile, fecal bile acid was slightly increased in GS guinea pigs after cholecystectomy, to the same degree as normal. These differences, however, were not significant. CONCLUSION: It is concluded that in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones: (1) Cholecystectomy produce a similar but less marked trend in bile acid pool; and (2) MMC are linked to enterohepatic circulation of bile acids, rather than surgery, which is consistent with changes of the bile acid pool size. As a result, gastrointestinal dyskinesia is not involved in occurrence of postchole-cystectomy syndrome.
机译：目的：研究胆囊切除术后胆汁酸池大小是否与豚鼠胃肠道迁移性肌电复合物（MMC）相关。方法：在胆囊切除术之前评估胆囊活动力。此外，我们在标准饮食组和高胆固醇饮食（胆固醇胆结石）组中，在手术前和术后4 wk期间，对有意识的豚鼠在手术前后使用双极电极连续监测消化道的胃肠动力。同时通过同位素稀释法测量总胆汁酸池大小。结果：胆囊切除术后，胆囊功能正常的豚鼠和胆固醇结石的豚鼠，Ⅰ，Ⅱ，Ⅲ期和MMC周期持续时间平行下降，但振幅增加。然而，两者之间并没有显着差异。另一方面，与正常的豚鼠相比，GS豚鼠的胆汁酸池肯定很小，并且在胆囊切除术后变小了。同样，GS豚鼠胆囊切除术后胆囊胆汁中的胆汁酸，粪便胆汁酸略有增加，与正常水平相同。但是，这些差异并不明显。结论：结论是，在胆囊功能正常的豚鼠和在胆固醇结石的豚鼠中：（1）胆囊切除术在胆汁酸池中产生相似但不明显的趋势； （2）MMC与胆汁酸的肠肝循环有关，而不是与手术有关，这与胆汁酸池大小的改变是一致的。结果，胃肠道运动障碍不参与胆囊切除术后综合征的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号