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首页> 外文期刊>World Journal of Gastroenterology >Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis.
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Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis.

机译：白蛋白，IGF-1，IGFBP-3在肝细胞癌肝硬化患者的肿瘤组织和邻近的非肿瘤组织中的表达。

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摘要

AIM: To explore the expression of albumin (ALB), insulin-like growth factor (IGF)-1, and insulin-like growth factor binding protein (IGFBP)-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma (HCC) patients with cirrhosis. METHODS: Twenty-four HCC patients with cirrhosis who underwent hepatectomy were studied. ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues (including tumor tissues and adjacent non-tumor tissues) were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Liver Ki67 immunohistochemistry staining was studied. At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal control. RESULTS: In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues. Liver Ki67 labeling index (Ki67 LI) in tumor tissues or adjacent non-tumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor tissues. CONCLUSION: Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.
机译：目的：探讨白蛋白（ALB），胰岛素样生长因子（IGF）-1和胰岛素样生长因子结合蛋白（IGFBP）-3在肝细胞癌（HCC）肿瘤组织和邻近非肿瘤组织中的表达）肝硬化患者。方法：对24例肝切除的肝硬化HCC患者进行了研究。通过逆转录聚合酶链反应（RT-PCR）检测肝组织（包括肿瘤组织和邻近的非肿瘤组织）中的ALB mRNA，IGF-1 mRNA和IGFBP-3 mRNA。研究了肝Ki67免疫组织化学染色。同时，将12例接受手术的胆石症或肝血管瘤患者作为正常对照。结果：在肝硬化肝癌患者中，肿瘤组织或邻近非肿瘤组织的肝ALB mRNA，IGF-1 mRNA和IGFBP-3 mRNA低于正常肝组织，而在肿瘤组织中，肝ALB mRNA和IGFBP- 3个mRNA水平较低，肝脏IGF-1 mRNA水平高于邻近的非肿瘤组织。肿瘤组织或邻近非肿瘤组织的肝脏Ki67标记指数（Ki67 LI）高于正常肝组织，而肿瘤组织中则高于邻近非肿瘤组织。结论：IGF-1和IGFBP-3的失衡可能与肝硬化患者的肝癌发生和肿瘤发展有关。

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