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首页> 外文期刊>World Journal of Gastroenterology >Gastrin and antral G cells in course of Helicobacter pylori eradication: Six months follow up study.
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Gastrin and antral G cells in course of Helicobacter pylori eradication: Six months follow up study.

机译：根除幽门螺杆菌过程中的胃泌素和胃窦G细胞：六个月的随访研究。

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AIM: To assess long-term effects of Helicobacter pylori (H pylori) eradication on antral G cell morphology and function in patients with and without duodenal ulcer (DU). METHODS: Consecutive dyspeptic patients referred to the endoscopy entered the study. Out of 39 H pylori positive patients, 8 had DU (H pylori +DU) and 31 gastritis (H pylori +G). Control groups consisted of 11 uninfected dyspeptic patients (CG1) and 7 healthy volunteers (CG2). Basal plasma gastrin (PGL), antral tissue gastrin concentrations (ATGC), immunohistochemical and electron microscopic characteristics of G cells were determined, prior to and 6 mo after therapy. RESULTS: We demonstrated elevated PGL in infected patients compared to uninfected controls prior to therapy. Elevated PGL were registered in all H pylori+patients (H pylori +DU: 106.78+/-22.72 pg/mL, H pylori +G: 74.95+/-15.63, CG1: 68.59+/-17.97, CG2: 39.24+/-5.59 pg/mL, P<0.01). Successful eradication (e) therapy in H pylori+patients lead to significant decrease in PGL (H pylori+DU: 59.93+/-9.40 and H pylori +Ge: 42.36+/-10.28 pg/mL, P<0.001). ATGC at the beginning of the study were similar in infected and uninfected patients and eradication therapy lead to significant decrease in ATGC in H pylori +gastritis, but not in DU patients. In the H pylori +DU patients, the mean number of antral G cells was significantly lower in comparison with all other groups (P<0.01), but after successful eradication was close to normal values found in controls. By contrast, G cell number and volume density were significantly decreased (P<0.01) in H pylori +Ge group after successful eradication therapy (294+/-32 and 0.31+/-0.02, respectively), in comparison to values before eradication (416+/-40 and 0.48+/-0.09). No significant change of the G cell/total endocrine cell ratio was observed during the 6 mo of follow up in any of the groups. A reversible increase in G cell secretory function was seen in all infected individuals, demonstrated by a more prominent secretory apparatus. However, differences between DU and gastritis group were identified. CONCLUSION: H pylori infection induces antral G cell hyperfunction resulting in increased gastrin synthesis and secretion. After eradication therapy complete morphological and functional recovery is observed in patients with gastritis. In the DU patients some other factors unrelated to the H pylori infection influence antral G cell morphology and function.
机译：目的：评估根除幽门螺杆菌（H pylori）对十二指肠溃疡（DU）和无十二指肠溃疡（DU）患者肛门G细胞形态和功能的长期影响。方法：将连续消化不良的患者转诊至内镜检查。在39例幽门螺杆菌阳性患者中，有8例患有DU（幽门螺杆菌+ DU）和31例胃炎（幽门螺杆菌+ G）。对照组由11名未感染的消化不良患者（CG1）和7名健康志愿者（CG2）组成。在治疗前和治疗后6个月测定基础血浆胃泌素（PGL），肛门组织胃泌素浓度（ATGC），G细胞的免疫组织化学和电子显微镜特征。结果：与治疗前未感染的对照组相比，我们证明了感染患者的PGL升高。在所有幽门螺杆菌+患者中均记录了升高的PGL（幽门螺杆菌+ DU：106.78 +/- 22.72 pg / mL，幽门螺杆菌+ G：74.95 +/- 15.63，CG1：68.59 +/- 17.97，CG2：39.24 +/- 5.59 pg / mL，P <0.01）。在幽门螺杆菌+患者中成功根除（e）治疗导致PGL显着降低（幽门螺杆菌+ DU：59.93 +/- 9.40和幽门螺杆菌+ Ge：42.36 +/- 10.28 pg / mL，P <0.001）。在研究开始时，ATGC在感染和未感染的患者中相似，根除治疗导致幽门螺杆菌+胃炎的ATGC显着降低，但在DU患者中却没有。在幽门螺杆菌+ DU患者中，与所有其他组相比，胃窦G细胞的平均数量明显减少（P <0.01），但成功根除后，其正常对照组的值接近正常值。相比之下，成功根除治疗后，幽门螺杆菌+ Ge组的G细胞数量和体积密度显着降低（P <0.01）（分别为294 +/- 32和0.31 +/- 0.02）（ 416 +/- 40和0.48 +/- 0.09）。在所有组中，随访的6个月内均未观察到G细胞/总内分泌细胞比例的显着变化。在所有被感染的个体中，G细胞分泌功能都可逆地增加，这是由更加突出的分泌装置所证实的。但是，DU和胃炎组之间存在差异。结论：幽门螺杆菌感染可引起肛门G细胞功能亢进，导致胃泌素合成和分泌增加。根除治疗后，胃炎患者可观察到完全的形态和功能恢复。在DU患者中，与幽门螺杆菌感染无关的其他一些因素会影响胃窦G细胞的形态和功能。

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