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首页> 外文期刊>World Journal of Gastroenterology >Visceral response to acute retrograde gastric electrical stimulation in healthy human
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Visceral response to acute retrograde gastric electrical stimulation in healthy human

机译：健康人对急性逆行胃电刺激的内脏反应

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AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with obesity. METHODS: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel electrogastrography. RESULTS: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in amplitude. The frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among individuals. CONCLUSION: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.
机译：目的：研究健康人对急性逆行胃电刺激（RGES）的内脏反应，并得出治疗肥胖患者的最佳参数。方法：通过在十二指肠健康人的胃幽门上方5 cm大曲率植入双极粘膜电极，进行具有一系列有效参数的RGES。在RGES期间，在包括长脉冲和脉冲序列在内的不同设置下，观察到了与消化不良和其他不适相关的症状并进行了分级。通过多通道胃电描记术记录基线和不同刺激设置期间的胃肌电活动。结果：所有受试者均以频率为9 cpm，脉冲宽度为500 ms，振幅为5 mA的起搏参数夹带胃慢波。刺激期间经常出现的症状是饱胀，腹胀，不适，疼痛，刺痛和恶心。随着在长脉冲和脉冲序列中将幅度或脉冲宽度调整为更高的比例，每个受试者的总症状评分显着增加。个人对RGES的内脏反应差异很大。结论：急性RGES可引起消化不良相关的一系列症状，有利于肥胖的治疗。最佳参数应根据个人对电刺激的敏感性来确定。

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