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首页> 外文期刊>World Journal of Gastroenterology >Resveratrol prolongs allograft survival after liver transplantation in rats.
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Resveratrol prolongs allograft survival after liver transplantation in rats.

机译：白藜芦醇可延长大鼠肝移植后的同种异体移植存活时间。

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AIM: To study the immuno-modulatory effect of resveratrol (RES) on allograft rejection after liver transplantation in rats. METHODS: Male Sprague-Dawley (SD) rats were selected as donors and male Wistar rats as recipients for a rejection model. The recipients were divided into four groups after orthotopic liver transplantation (OLTx). In the RES A, B, and C groups, RES was given intra-peritoneally once a day (25, 50, and 100 mg/kg, respectively) after OLTx, whereas in the control group, vehicle buffer was given intra-peritoneally once a day. The survival time, serum chemistry, production of cytokines, activation of transcription factor NF-kappaB, and histopathologic findings were then compared among these groups. RESULTS: The mean survival time after OLTx in the RES C group was significantly longer than that in the control group (16.7+/-1.2 d vs 9.3+/-0.6 d, P<0.01). On the 7th post-transplant day the serum albumin level significantly improved in the RES C group, the serum total bile acid and alanine aminotransferase (ALT) levels were significantly lower in the RES C group, the serum IL-2 and INF-gamma levels were significantly lower in the RES C group, and the activation of transcription factor NF-kappaB in peripheral blood T lymphocytes was significantly suppressed in the RES A, B, and C groups in comparison to those in the control group. On the 7th post-transplant day, a histological examination revealed apparent difference in the severity of rejection between the RES C group and control group. CONCLUSION: RES has an immuno-suppressive property as well as protective effect on hepatocytes under allograft rejection. It might serve as a novel agent for reducing the severity of hepatic allograft rejection in rats.
机译：目的：研究白藜芦醇（RES）对大鼠肝移植后异体移植排斥反应的免疫调节作用。方法：选择雄性Sprague-Dawley（SD）大鼠作为供体，雄性Wistar大鼠作为排斥模型的受体。原位肝移植（OLTx）后将接受者分为四组。在RES A，B和C组中，每天OLTx一次腹膜内给予RES（分别为25、50和100 mg / kg），而在对照组中，一次腹膜内给予媒介缓冲剂一天。然后比较这些组的存活时间，血清化学，细胞因子的产生，转录因子NF-κB的活化以及组织病理学发现。结果：RES C组OLTx术后平均生存时间明显长于对照组（16.7 +/- 1.2 d vs 9.3 +/- 0.6 d，P <0.01）。移植后第7天，RES C组血清白蛋白水平明显改善，RES C组血清总胆汁酸和丙氨酸氨基转移酶（ALT）水平明显降低，血清IL-2和INF-γ水平与对照组相比，RES C组中的TNF-α显着降低，并且在RES A，B和C组中外周血T淋巴细胞中转录因子NF-κB的活化被显着抑制。移植后第7天，组织学检查发现RES C组与对照组之间排斥反应的严重程度存在明显差异。结论：RES在同种异体移植排斥反应下具有免疫抑制作用以及对肝细胞的保护作用。它可能作为减少大鼠肝移植排斥反应严重程度的新型药物。

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