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首页> 外文期刊>World Journal of Gastroenterology >Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.
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Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.

机译：日语中的克罗恩氏病与N-乙酰基转移酶2基因的SNP单倍型有关。

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摘要

AIM: To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD). METHODS: Frequencies and distributions of NAT2 and UGT1A7 SNPs as well as their haplotypes were investigated in 95 patients with UC, 60 patients with CD, and 200 gender-matched, unrelated, healthy, control volunteers by PCR-restriction fragment length polymorphism (RFLP), PCR-denaturing high-performance liquid chromatography (DHPLC), and direct DNA sequencing. RESULTS: Multiple logistic regression analysis revealed that the frequency of haplotype, NAT2*7B, significantly increased in CD patients, compared to that in controls (P = 0.0130, OR = 2.802, 95%CI = 1.243-6.316). However, there was no association between NAT2 haplotypes and UC, or between any UGT1A7 haplotypes and inflammatory bowel disease (IBD). CONCLUSION: It is likely that the NAT2 gene is one of the determinants for CDin Japanese. Alternatively, a new CD determinant may exist in the 8p22 region, where NAT2 is located.
机译：目的：研究溃疡性结肠炎（UC）和克罗恩病（CD）患者中N-乙酰基转移酶2（NAT2）和尿苷5'-二磷酸（UDP）-葡萄糖醛酸转移酶1A7（UGT1A7）基因的频率和分布。方法：采用PCR-限制性片段长度多态性（RFLP）技术，对95例UC患者，60例CD患者和200例性别匹配，无关，健康的对照志愿者中的NAT2和UGT1A7 SNPs的频率，分布及其单倍型进行了研究。 ，PCR变性高效液相色谱（DHPLC）和直接DNA测序。结果：多重logistic回归分析显示，与对照组相比，CD患者单倍型NAT2 * 7B的频率显着增加（P = 0.0130，OR = 2.802，95％CI = 1.243-6.316）。但是，NAT2单倍型与UC之间，或任何UGT1A7单倍型与炎症性肠病（IBD）之间没有关联。结论：NAT2基因可能是日语中CD的决定因素之一。或者，在NAT2所在的8p22区域中可能存在新的CD决定因素。

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