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首页> 外文期刊>World Journal of Gastroenterology >1.5 Harmonic Imaging Sonography with microbubble contrast agent improves characterization of hepatocellular carcinoma.
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1.5 Harmonic Imaging Sonography with microbubble contrast agent improves characterization of hepatocellular carcinoma.

机译：1.5带有微泡造影剂的谐波成像超声可以改善肝细胞癌的特征。

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AIM: To investigate the usefulness of 1.5 Harmonic Imaging Sonography with the use of the contrast agent Levovist for the diagnosis of hepatocellular carcinoma (HCC) and for the evaluation of therapeutic response. METHODS: Phantom experiments were performed to compare the contrast effects of 2(nd) harmonic imaging and 1.5 Harmonic Imaging Sonography. 1.5 Harmonic Imaging Sonography was employed to examine 36 patients with HCC (42 nodules) before and after the treatment and to compare against the findings obtained using other diagnostic imaging modalities. RESULTS: In 1.5 Harmonic Imaging Sonography, the tumor vessels of HCCs were clearly identified during the early phase, and late-phase images clearly demonstrated the differences in contrast enhancement between the tumor and surrounding hepatic parenchyma. Blood flow within the tumor was detected in 36 nodules (85.7%) during the early phase and in all 42 nodules (100%) during the late phase using 1.5 Harmonic Imaging Sonography, in 38 nodules (90.5%) using contrast-enhanced CT, in 34 nodules (81.0%) using digital subtraction angiography (DSA), and in 42 nodules (100%) using US CO(2) angiography. Following transcatheter arterial embolization, 1.5 Harmonic Imaging Sonography detected blood flow and contrast enhancement within the tumors that were judged to contain viable tissue in 20 of 42 nodules (47.6%). However, 6 of these 10 cases were not judged in contrast-enhanced CT. 1.5 Harmonic Imaging Sonography was compared with the US CO(2) angiography findings as the gold standard, and the sensitivity and specificity of these images for discerning viable and nonviable HCC after transcatheter arterial embolization were 100% and 100%, respectively. CONCLUSION: 1.5 Harmonic Imaging Sonography permits the vascular structures of HCCs to be identified and blood flow within the tumor to be clearly demonstrated. Furthermore, 1.5 Harmonic Imaging Sonography is potentially useful for evaluating the therapeutic effects of transcatheter arterial embolization on HCC.
机译：目的：探讨1.5次谐波成像超声检查与造影剂Levovist在诊断肝细胞癌（HCC）和评估治疗反应中的作用。方法：进行了幻影实验，比较了2次谐波成像和1.5次谐波成像超声的对比效果。 1.5谐波成像超声检查用于检查治疗前后的36例HCC（42个结节）患者，并与使用其他诊断成像方式获得的结果进行比较。结果：在1.5谐波超声检查中，早期发现了肝癌的肿瘤血管，而晚期成像则清楚地表明了肿瘤与周围肝实质之间对比增强的差异。使用1.5 Harmonic Imaging Sonography在早期检测到36个结节（85.7％）的肿瘤内的血流，在后期使用1.5谐波成像超声检查检测到所有42个结节（100％）的血流，使用对比增强CT在38个结节（90.5％）进行了检测，使用数字减影血管造影（DSA）的34个结节（81.0％），以及使用美国CO（2）血管造影的42个结节（100％）。经导管动脉栓塞后，1.5 Harmonic Imaging Sonography在42个结节中有20个结节（47.6％）中检测到肿瘤内的血流和造影剂增强。但是，这10例病例中有6例未通过造影剂CT进行判断。 1.5将谐波成像超声检查与美国CO（2）血管造影检查结果作为金标准进行了比较，这些图像对经导管动脉栓塞后可分辨的肝细胞癌和不可见肝癌的敏感性和特异性分别为100％和100％。结论：1.5谐波超声检查可以识别HCC的血管结构，并清楚显示肿瘤内的血流。此外，1.5谐波成像超声检查对于评估经导管动脉栓塞对HCC的治疗效果可能有用。

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